Saha N, Tay J S, Low P S, Basair J B
Department of Paediatrics, National University of Singapore.
Ann Hum Biol. 1992 May-Jun;19(3):277-83. doi: 10.1080/03014469200002142.
The distribution of plasma coagulation factor XXIIB polymorphism was determined by PAG isoelectric focusing and immunoblotting in a group of 670 subjects comprising 375 Chinese, 110 Malays and 185 Indians. The frequencies of FXIIIB1, FXIIIB2, and FXIIIB*3 were found to be 0.27, 0.03 and 0.70 in the Chinese; 0.33, 0.05 and 0.64 in the Malays and 0.58, 0.08 and 0.33 in the Indians. The phenotypic distribution of FXIIIB alleles was at Hardy-Weinberg equilibrium in all three populations. A two-dimensional principal-components analysis on the basis of three common alleles at the FXIIIB locus among 19 populations, so far studied, clearly differentiates the Negroid, Mongoloid and Caucasoid populations into three major groups with the exception of Amerindians (Minnesota) and US Blacks showing some Caucasoid influence.
采用聚丙烯酰胺等电聚焦和免疫印迹法，对由375名中国人、110名马来人和185名印度人组成的670名受试者群体进行血浆凝血因子XXIIB多态性分布测定。结果发现，在中国人群中，FXIIIB1、FXIIIB2和FXIIIB*3的频率分别为0.27、0.03和0.70；在马来人群中分别为0.33、0.05和0.64；在印度人群中分别为0.58、0.08和0.33。在所有这三个人群中，FXIIIB等位基因的表型分布均处于哈迪-温伯格平衡。基于迄今所研究的19个人群中FXIIIB位点的三个常见等位基因进行的二维主成分分析，除显示出一些高加索人影响的美洲印第安人（明尼苏达州）和美国黑人外，能明确地将黑人、蒙古人种和高加索人种群体分为三大类。
