• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Immunology: To affinity and beyond.

作者信息

Tarlinton David M

机构信息

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia, and in the Department of Medical Biology, University of Melbourne, Parkville.

出版信息

Nature. 2014 May 29;509(7502):573-4. doi: 10.1038/509573a.

DOI:10.1038/509573a
PMID:24870540
Abstract
摘要

相似文献

1
Immunology: To affinity and beyond.免疫学:从亲和力到更远的领域。
Nature. 2014 May 29;509(7502):573-4. doi: 10.1038/509573a.
2
Clonal selection in the germinal centre by regulated proliferation and hypermutation.生发中心中通过调节增殖和超突变的克隆选择。
Nature. 2014 May 29;509(7502):637-40. doi: 10.1038/nature13300. Epub 2014 May 4.
3
Med1 deficiency alters the somatic hypermutation spectrum in murine B cells.Med1 缺乏改变了小鼠 B 细胞中的体细胞超突变谱。
Eur J Immunol. 2018 Apr;48(4):720-723. doi: 10.1002/eji.201747258. Epub 2018 Feb 14.
4
Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation.错失中心:重新思考抗体亲和力成熟的要求。
Immunity. 2015 Jul 21;43(1):5-6. doi: 10.1016/j.immuni.2015.07.002.
5
AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.AID 靶向和非免疫球蛋白基因的超突变与生发中心 B 细胞中免疫球蛋白基因的邻近性无关。
PLoS One. 2012;7(6):e39601. doi: 10.1371/journal.pone.0039601. Epub 2012 Jun 29.
6
High affinity IgM(+) memory B cells are generated through a germinal center-dependent pathway.高亲和力IgM(+)记忆B细胞通过生发中心依赖途径产生。
Mol Immunol. 2015 Dec;68(2 Pt C):617-27. doi: 10.1016/j.molimm.2015.10.003. Epub 2015 Oct 26.
7
AID expression during B-cell development: searching for answers.在 B 细胞发育过程中 AID 的表达:寻找答案。
Immunol Res. 2011 Apr;49(1-3):3-13. doi: 10.1007/s12026-010-8185-7.
8
Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.沙门氏菌感染引发混乱的B细胞激活,随后是滤泡外亲和力成熟。
Immunity. 2015 Jul 21;43(1):120-31. doi: 10.1016/j.immuni.2015.06.013. Epub 2015 Jul 14.
9
Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification.鉴定免疫库形成或特异性缺陷的 CVID 患者。
Front Immunol. 2018 Nov 23;9:2545. doi: 10.3389/fimmu.2018.02545. eCollection 2018.
10
Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction.慢性丙型肝炎病毒感染个体的肝内 B 细胞滤泡缺乏异位生发中心反应的迹象。
Eur J Immunol. 2014 Jun;44(6):1842-50. doi: 10.1002/eji.201344378. Epub 2014 Apr 14.

引用本文的文献

1
Gold-Nanostar-Chitosan-Mediated Delivery of SARS-CoV-2 DNA Vaccine for Respiratory Mucosal Immunization: Development and Proof-of-Principle.金纳米星壳聚糖介导的 SARS-CoV-2 DNA 疫苗经呼吸道黏膜免疫传递:研发与原理验证。
ACS Nano. 2021 Nov 23;15(11):17582-17601. doi: 10.1021/acsnano.1c05002. Epub 2021 Oct 27.
2
Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity.血凝素功能化脂质体疫苗增强生发中心和滤泡辅助性T细胞免疫。
Adv Healthc Mater. 2021 May;10(10):e2002142. doi: 10.1002/adhm.202002142. Epub 2021 Mar 9.
3
T Cells Induced by Vaccination and Following SIV Challenge Support Env-Specific Humoral Immunity in the Rectal-Genital Tract and Circulation of Female Rhesus Macaques.

本文引用的文献

1
Clonal selection in the germinal centre by regulated proliferation and hypermutation.生发中心中通过调节增殖和超突变的克隆选择。
Nature. 2014 May 29;509(7502):637-40. doi: 10.1038/nature13300. Epub 2014 May 4.
2
Diversity among memory B cells: origin, consequences, and utility.记忆 B 细胞的多样性:起源、后果和应用。
Science. 2013 Sep 13;341(6151):1205-11. doi: 10.1126/science.1241146.
3
Germinal centers.生发中心。
接种疫苗及感染猴免疫缺陷病毒(SIV)后诱导产生的T细胞可支持恒河猴雌性直肠生殖道及循环系统中针对Env的体液免疫。
Front Immunol. 2021 Jan 28;11:608003. doi: 10.3389/fimmu.2020.608003. eCollection 2020.
4
Mathematical modeling of lymphocytes selection in the germinal center.生发中心淋巴细胞选择的数学建模。
J Math Biol. 2017 Mar;74(4):933-979. doi: 10.1007/s00285-016-1038-9. Epub 2016 Aug 11.
5
Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma.大规模平行IGHV基因测序揭示了人类多发性骨髓瘤起源中的生发中心途径。
Oncotarget. 2015 May 30;6(15):13229-40. doi: 10.18632/oncotarget.3644.
Annu Rev Immunol. 2012;30:429-57. doi: 10.1146/annurev-immunol-020711-075032. Epub 2012 Jan 3.
4
Follicular helper CD4 T cells (TFH).滤泡辅助性 CD4 T 细胞(TFH)。
Annu Rev Immunol. 2011;29:621-63. doi: 10.1146/annurev-immunol-031210-101400.
5
Quantitative regulation of B cell division destiny by signal strength.信号强度对B细胞分裂命运的定量调控。
J Immunol. 2008 Jul 1;181(1):374-82. doi: 10.4049/jimmunol.181.1.374.
6
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.生发中心暗区和亮区的组织由CXCR4和CXCR5介导。
Nat Immunol. 2004 Sep;5(9):943-52. doi: 10.1038/ni1100. Epub 2004 Aug 1.
7
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.类别转换重组和高频突变需要激活诱导的胞嘧啶脱氨酶(AID),一种潜在的RNA编辑酶。
Cell. 2000 Sep 1;102(5):553-63. doi: 10.1016/s0092-8674(00)00078-7.
8
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response.在初次免疫应答中,记忆细胞和抗体形成细胞区室的亲和力成熟程度有所不同。
EMBO J. 1997 Jun 2;16(11):2996-3006. doi: 10.1093/emboj/16.11.2996.
9
Germinal centers.生发中心
Annu Rev Immunol. 1994;12:117-39. doi: 10.1146/annurev.iy.12.040194.001001.