卵巢浆液性乳头状囊腺癌中19号染色体短臂增加标记染色体及11号染色体短臂物质缺失的一致性出现。
Consistent occurrence of a 19p+ marker chromosome and loss of 11p material in ovarian seropapillary cystadenocarcinomas.
作者信息
Pejovic T, Heim S, Mandahl N, Elmfors B, Flodérus U M, Furgyik S, Helm G, Willén H, Mitelman F
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Genes Chromosomes Cancer. 1989 Nov;1(2):167-71. doi: 10.1002/gcc.2870010210.
Cytogenetic analysis of short-term cultures from 11 moderately to poorly differentiated ovarian seropapillary cystadenocarcinomas revealed clonal chromosomal abnormalities in nine tumors. Two bands were involved in structural rearrangements in more than half of the tumors. The band most frequently affected was 19p13; rearrangements giving rise to a 19p+ marker chromosome were found in seven tumors, and in four of them the 19p+ markers appeared to be identical. Structural rearrangements resulting in loss of 11p13-11pter material were found in six tumors.
对11例中低分化卵巢浆液性乳头状囊腺癌的短期培养物进行细胞遗传学分析，结果显示9例肿瘤存在克隆性染色体异常。超过半数的肿瘤中有两条带发生了结构重排。最常受影响的带是19p13；在7例肿瘤中发现了导致19p +标记染色体的重排，其中4例的19p +标记似乎相同。在6例肿瘤中发现了导致11p13 - 11pter物质缺失的结构重排。
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