Pejovic T, Heim S, Mandahl N, Elmfors B, Furgyik S, Flodérus U M, Helm G, Willén H, Mitelman F
Department of Clinical Genetics, Lund University Hospital, Sweden.
Int J Cancer. 1991 Feb 1;47(3):358-61. doi: 10.1002/ijc.2910470308.
Cytogenetic analyses were performed on the tumors from both ovaries in 15 patients with bilateral ovarian carcinoma. In 4 of them, omental implants were also examined. Abnormal karyotypes were detected in 11 cases. The baseline karyotypes in the 2 tumorous ovaries were identical in each patient, indicating that bilateral ovarian cancer develops by metastatic spreading. There was no clear-cut evidence of differences in the clonal evolution between the tumors of the 2 ovaries, and hence the side harboring the primary tumor could never be determined. The metastatic nature of the omental implants was proved by the fact that their karyotypes were indistinguishable from those of the ovarian tumor tissue.
对15例双侧卵巢癌患者双侧卵巢的肿瘤进行了细胞遗传学分析。其中4例还检查了大网膜种植灶。11例检测到异常核型。每位患者双侧肿瘤性卵巢的基线核型相同，表明双侧卵巢癌是通过转移扩散发展而来。没有明确证据表明双侧卵巢肿瘤的克隆进化存在差异，因此无法确定原发肿瘤所在侧。大网膜种植灶的核型与卵巢肿瘤组织的核型无法区分，这证明了其转移性质。
