Chylack L T, Leske M C, Khu P, McCarthy D, Wu S Y
Center for Clinical Cataract Research, Brigham and Women's Hospital.
Lens Eye Toxic Res. 1989;6(4):515-22.
The Lens Opacities Classification System (LOCS II) has been tested as a method for detecting and grading longitudinal changes in cataract severity. The LOCS I and II systems have already been tested and validated for cross-sectional classification of human cataracts in vivo. 130 eyes (of 68 patients) were photographed at baseline and follow-up visits with Neitz CTR and Zeiss slit photography. The mean length of follow-up was 14.7 +/- 4.4 months. The severity of nuclear opalescence (NO), cortical (C) and posterior subcapular cataract (P) was graded in a masked fashion using the LOCS II standards. Side-by-side comparisons of baseline and follow-up photos were also done in a masked fashion to detect more subtle changes than might be evident in the LOCS II gradings. The annual percent progression in cataracts graded by LOCS II standards are: (NO): 12.4%, (C): 17.9%, and (P): 6.5%. The LOCS II standards are offered as a promising subjective method for longitudinal grading of human cataractous change in vivo.
晶状体混浊分类系统（LOCS II）已作为一种检测和分级白内障严重程度纵向变化的方法进行了测试。LOCS I和II系统已在体内对人类白内障的横断面分类进行了测试和验证。对68例患者的130只眼睛在基线和随访时用Neitz CTR和蔡司裂隙摄影进行拍照。平均随访时间为14.7±4.4个月。使用LOCS II标准以盲法对核混浊（NO）、皮质（C）和后囊下白内障（P）的严重程度进行分级。还以盲法对基线和随访照片进行并排比较以检测比LOCS II分级中可能明显的更细微变化。按照LOCS II标准分级的白内障年进展百分比为：（NO）：12.4%，（C）：17.9%，（P）：6.5%。LOCS II标准是一种很有前景的主观方法，用于体内人类白内障变化的纵向分级。
