García Luna A, González Diddi M, Murrieta S, Guzmán F, Alvarado Durán A
Ginecol Obstet Mex. 1989 Mar;57:76-81.
In our IVF + ET & GIFT programs we gave 100 mg of clomiphene from cycle days 2 to 6 in 35 cycles of 32 infertile patients. Serum estradiol curves were made establishing 3 types of curves: 1. climbing curve which was subdivided in curve A (6 cycles) with more than 600 pg/mL of estradiol, more than 4 follicles of a mean size of 35 mm; curve B (13 cycles) with an estradiol range from 300 to 600 pg/mL, 2.9 follicles of 24 mm and curve C with less than 300 pg/mL of estradiol, 0.8 follicles of 22 mm. 2. Flat curve with minimum estradiol level and follicle size and 3. Irregular curve with atypic variations that probably reflect oocyte atresia and cyst formation. The progesterone level in the luteal phase was parallel to the estradiol. There was evidence of multiple follicular growth in 20 cycles (57%). Nine laparoscopies for ovum capture were made, collecting a mean of 1.2 oocytes per laparoscopy; they were fertilized in vitro and later transferred 4 embryos and 4 oocytes were transferred to the fallopian tubes. There was at most one mature oocyte per laparoscopy. No pregnancies were achieved. The clomiphene as a single agent, for its wide availability, might be choice for some women that show a good response, which might depend on several factors, but it cannot be considered the ideal single agent for programs that include ovum pick ups.
在我们的体外受精+胚胎移植及配子输卵管内移植项目中，我们对32名不孕患者的35个周期从周期第2天至第6天给予100毫克克罗米芬。绘制了血清雌二醇曲线，确定了3种类型的曲线：1. 上升曲线，该曲线又细分为曲线A（6个周期），雌二醇超过600皮克/毫升，超过4个卵泡，平均大小为35毫米；曲线B（13个周期），雌二醇范围为300至600皮克/毫升，2.9个卵泡，大小为24毫米；曲线C，雌二醇低于300皮克/毫升，0.8个卵泡，大小为22毫米。2. 最低雌二醇水平和卵泡大小的平坦曲线。3. 具有非典型变化的不规则曲线，这可能反映了卵母细胞闭锁和囊肿形成。黄体期的孕酮水平与雌二醇平行。有证据表明20个周期（57%）出现多个卵泡生长。进行了9次腹腔镜取卵，每次腹腔镜平均采集1.2个卵母细胞；将它们体外受精，随后移植了4个胚胎，并将4个卵母细胞移植到输卵管。每次腹腔镜最多有1个成熟卵母细胞。未实现妊娠。克罗米芬作为单一药物，因其广泛可得性，对于一些反应良好的女性可能是一种选择，这可能取决于几个因素，但对于包括取卵的项目，它不能被视为理想的单一药物。
