Bates R G, Fielding P M, Lindsay K S, White N J, Edmonds D K
Chelsea Hospital for Women, London.
Br J Obstet Gynaecol. 1988 Dec;95(12):1220-5. doi: 10.1111/j.1471-0528.1988.tb06809.x.
Thirty-three patients with unexplained infertility underwent a total of 42 programmed superovulation cycles in a gamete intrafallopian transfer (GIFT) programme. The date of oocyte retrieval was decided in advance and the cycle preceding oocyte collection was modified with norethisterone from mid-cycle until 14 days before the scheduled laparoscopy. This was followed by a fixed schedule superovulation regimen. Serum oestradiol, progesterone and luteinizing hormone were monitored and the data analysed retrospectively. A single ultrasound scan was performed on the day of laparoscopy to exclude ovulation. Thirty-eight GIFT procedures were performed, resulting in 11 (29%) clinical pregnancies of which four twin and four singleton pregnancies are continuing. There was a significant correlation between the oestradiol response pattern and the maturity of oocytes retrieved, the fertilization rate of supernumerary oocytes and the pregnancy rate. Programmed cycles may be conveniently combined with GIFT, and basic endocrinological monitoring can be used to identify cycles with a poor prognosis before laparoscopy.
33例不明原因不孕症患者在配子输卵管内移植（GIFT）计划中总共经历了42个程序化超排卵周期。取卵日期提前确定，在预定腹腔镜检查前14天，从周期中期开始用炔诺酮对取卵前的周期进行调整。随后采用固定方案的超排卵方案。监测血清雌二醇、孕酮和促黄体生成素，并对数据进行回顾性分析。在腹腔镜检查当天进行一次超声扫描以排除排卵。共进行了38次GIFT手术，结果有11例（29%）临床妊娠，其中4例双胎妊娠和4例单胎妊娠仍在继续。雌二醇反应模式与所取卵母细胞的成熟度、多余卵母细胞的受精率和妊娠率之间存在显著相关性。程序化周期可以方便地与GIFT相结合，并且基本的内分泌监测可用于在腹腔镜检查前识别预后不良的周期。
