Teyssler Petr, Kolostova Katarina, Bobek Vladimir
Acta Orthop Belg. 2014 Mar;80(1):11-7.
Untreated chronic haemophiliac synovitis leads to the development of haemophilic arthropathy (HA) by affecting the metabolism of chondrocytes. Symptoms are progressive and often surgical intervention is required to prevent total loss of joint function. The focus of our study was to influence the chronic haemophiliac synovitis by means of autologous platelet-rich plasma (PRP) injection. Six patients with hemophilia (PWH), aged between 9 and 45 and manifesting chronic synovitis of the ankle joint on one or on both sides (8 joints in total) were included into the PRP-study. The patients were classified depending on their joint status using the Hemophilia Joint Health Score (HJHS) prior to and again two months after treatment. Three to five ml of PRP was injected into the joint cavity within 30 seconds. In all of the tested PWH pain relief has been reported subjectively by means of the HJHS and VAS scoring systems, comparing the pain intensity before PRP injection and two months after. The difference of pain perception has been found statistically significant for the VAS-scores. Considering the objective synovitis signs shown on MRI before and after PRP injection we recorded a decrease in the volume of free synovial fluid after PRP. All of the tested patients reported benefit of the PRP therapy.
未经治疗的慢性血友病性滑膜炎会通过影响软骨细胞的代谢导致血友病性关节病（HA）的发展。症状是渐进性的，通常需要手术干预以防止关节功能完全丧失。我们研究的重点是通过自体富血小板血浆（PRP）注射来影响慢性血友病性滑膜炎。六名年龄在9至45岁之间、一侧或双侧踝关节出现慢性滑膜炎（共8个关节）的血友病患者（PWH）被纳入PRP研究。在治疗前和治疗后两个月，根据血友病关节健康评分（HJHS）对患者的关节状况进行分类。在30秒内将3至5毫升PRP注入关节腔。在所有接受测试的PWH中，通过HJHS和视觉模拟评分（VAS）系统主观报告了疼痛缓解情况，比较了PRP注射前和注射后两个月的疼痛强度。发现VAS评分的疼痛感知差异具有统计学意义。考虑到PRP注射前后MRI显示的客观滑膜炎体征，我们记录到PRP治疗后游离滑液体积减少。所有接受测试的患者均报告了PRP治疗的益处。
