Hong S Y, Pyo S J, Kim M H, Kim S K, Park I S, Oh D Y, Kim S J
Korean J Intern Med. 1989 Jan;4(1):48-53. doi: 10.3904/kjim.1989.4.1.48.
The purpose of this study was to find out the range and distribution of fibrinolytic response to standardized venous occlusion in healthy volunteers and to determine whether there were any differences according to age and sex. In 118 healthy volunteers (55 males, 63 females) of various age groups, the total fibrinolytic activity in euglobulin fractions was measured by a well controlled fibrin plate method before and after venous occlusion of 5 minutes at 100 mmHg. The difference between our method and previous methods is that we occluded for a relatively shorter duration than that of previous studies (15-20 minutes) at constant pressure (100 mmHg), instead of midway between systolic and diastolic pressure. This method was reliable and reproducible as a tool to qualify and assess the fibrinolytic activity capacity of individuals. The results showed that there was no difference in basal fibrinolytic activity and the response to stimuli in various age groups (p greater than 0.25) and in male and female groups (0.1 less than p less than 0.375).
本研究的目的是找出健康志愿者对标准化静脉闭塞的纤溶反应范围和分布情况，并确定是否存在年龄和性别差异。在118名不同年龄组的健康志愿者（55名男性，63名女性）中，通过严格控制的纤维蛋白平板法在100 mmHg压力下进行5分钟静脉闭塞前后，测定优球蛋白组分中的总纤溶活性。我们的方法与以往方法的不同之处在于，我们在恒定压力（100 mmHg）下闭塞的持续时间比以往研究（15 - 20分钟）相对较短，而不是在收缩压和舒张压之间的中间值。作为一种鉴定和评估个体纤溶活性能力的工具，该方法可靠且可重复。结果表明，各年龄组（p大于0.25）以及男性和女性组（0.1小于p小于0.375）的基础纤溶活性和对刺激的反应均无差异。
