偏头痛、脑白质高信号、社区人群亚临床脑梗死：北方曼哈顿研究。
Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community: the northern Manhattan study.
机构信息
From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
出版信息
Stroke. 2014 Jun;45(6):1830-2. doi: 10.1161/STROKEAHA.114.005447. Epub 2014 May 15.
BACKGROUND AND PURPOSE
Migraine with aura is a risk factor for ischemic stroke. The goals of this study are to examine the association between migraine and subclinical cerebrovascular damage in a race/ethnically diverse older population-based cohort study.
METHODS
In the Northern Manhattan Study (NOMAS), we quantified subclinical brain infarctions and white matter hyperintensity volumes among participants with self-reported migraine, confirmed by the International Classification of Headache Disorders-2 criteria.
RESULTS
Of 546 study participants with imaging and migraine data (41% men; mean age at MRI, 71±8 years; mostly Hispanic [65%]), those reporting migraine overall had double the odds of subclinical brain infarction (adjusted odds ratio, 2.1; 95% confidence interval, 1.0-4.2) when compared with those reporting no migraine, after adjusting for sociodemographics and vascular risk factors. No association was observed between migraine with or without aura and white matter hyperintensity volume.
CONCLUSIONS
Migraine may be a risk factor for subclinical brain infarction. Prospective studies are needed in race/ethnically diverse populations.
背景与目的
有先兆偏头痛是缺血性卒中的一个危险因素。本研究的目的是在一个种族/民族多样化的基于人群的队列研究中，检查偏头痛与亚临床脑血管损伤之间的关系。
方法
在北方曼哈顿研究（NOMAS）中，我们根据国际头痛疾病分类-2 标准，在有自我报告偏头痛（经确认）的参与者中定量评估了亚临床脑梗死和脑白质高信号体积。
结果
在有影像学和偏头痛数据的 546 名研究参与者中（41%为男性；MRI 时的平均年龄为 71±8 岁；大多数为西班牙裔[65%]），与无偏头痛报告者相比，整体报告偏头痛者发生亚临床脑梗死的几率增加了一倍（调整后的优势比，2.1；95%置信区间，1.0-4.2），校正了社会人口统计学和血管危险因素。偏头痛伴或不伴先兆与脑白质高信号体积之间无关联。
结论
偏头痛可能是亚临床脑梗死的一个危险因素。在种族/民族多样化的人群中需要进行前瞻性研究。
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