Koontz M A, Hendrickson A E, Ryan M K
Department of Ophthalmology, University of Washington School of Medicine, Seattle 98195.
Vis Neurosci. 1989;2(1):19-25. doi: 10.1017/s0952523800004284.
Synaptic contacts onto fibers and somata in the nerve fiber layer (NFL) and ganglion cell layer (GCL) of macaque and human retina were demonstrated at the electron microscopical (EM) level. Many presynaptic processes in monkey NFL are gamma aminobutyric acid (GABA) immunoreactive, using anti-GABA antiserum with an EM immunogold procedure. Immunocytochemistry at the light microscopic level revealed that many GABA-reactive cells in the GCL send branching processes into the NFL, forming a sparse synaptic plexus. The presence of long, unbranched GABA-reactive fibers running horizontally in the NFL and entering the optic nerve suggests that some ganglion cells may be GABAergic. GABA-reactive cells contributing to the plexus appear to be a new class of displaced amacrines that arborize in the NFL.
在电子显微镜（EM）水平上证实了猕猴和人类视网膜神经纤维层（NFL）和神经节细胞层（GCL）中纤维和胞体上的突触联系。使用抗γ-氨基丁酸（GABA）抗血清和EM免疫金程序，猴子NFL中的许多突触前过程呈GABA免疫反应性。光镜水平的免疫细胞化学显示，GCL中许多GABA反应性细胞向NFL发出分支突起，形成稀疏的突触丛。在NFL中水平延伸并进入视神经的长而无分支的GABA反应性纤维的存在表明，一些神经节细胞可能是GABA能的。对突触丛有贡献的GABA反应性细胞似乎是一类新的移位无长突细胞，它们在NFL中形成分支。
