Pun Amy H, Kasmeridis Harry, Rieger Nicholas, Loganathan Arun
Discipline of Surgery, The Queen Elizabeth Hospital, Adelaide, SA, Australia.
Anatomical Pathology, The Queen Elizabeth Hospital, Adelaide, SA, Australia.
J Surg Case Rep. 2014 Mar 20;2014(3):rju013. doi: 10.1093/jscr/rju013.
Enteropathy-associated T cell lymphoma (EATCL) is an intestinal neoplasm of intra-epithelial T lymphocytes associated with coeliac disease. Although the incidence is rare, EATCL runs an aggressive disease course and produces multi-focal ulcerative lesions most commonly in the proximal small bowel. As such, patients may present with intestinal perforation, obstruction or haemorrhage. Management of EATCL requires a combination of early diagnosis and treatment by surgical resection followed by chemotherapy to achieve treatment success. Overall however, the treatment completion rate remains at 50% and EATCL carries a poor prognosis with a 5-year survival rate of <20%.
肠病相关T细胞淋巴瘤(EATCL)是一种与乳糜泻相关的上皮内T淋巴细胞肠道肿瘤。尽管发病率很低,但EATCL病程进展迅速,最常于近端小肠产生多灶性溃疡性病变。因此,患者可能出现肠穿孔、肠梗阻或出血。EATCL的治疗需要早期诊断并结合手术切除及化疗,以取得治疗成功。然而总体而言,治疗完成率仍为50%,EATCL预后较差,5年生存率<20%。