Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesia, Tianjin, People's Republic of China.
The Xiangya Medical School of Central-South University, Changsha, People's Republic of China.
Onco Targets Ther. 2014 May 13;7:729-37. doi: 10.2147/OTT.S61033. eCollection 2014.
To examine oncologists' knowledge of cancer pain and morphine's clinical application in the People's Republic of China. In addition, this study analyzes and discusses the negative factors that currently affect the clinical application of morphine.
A questionnaire survey was given to a random sample of 150 oncologists from Tianjin Medical University Cancer Institute and Hospital. The statistical results were analyzed and processed using SPSS version 21.0 and Matlab version 2012a statistical software. Single-factor analysis of variance, Kruskal-Wallis nonparametric test, and independent samples t-test were adopted to analyze the difference in knowledge scores of morphine usage. The study also identified major impediment factors on clinical use of morphine.
Among the 127 respondents, morphine controlled-release tablets were the most popular drug chosen to treat severe cancer pain (76 respondents, 35.8%). Participants who reported having received training in cancer pain management and drug use demonstrated a significantly higher mean score of basic knowledge compared with their untrained peers (11.51±2.60 versus 9.28±3.68, t=2.48, P=0.022). The top four barriers to widespread clinical use of morphine for cancer pain were 1) insufficient analgesia administration training for medical personnel, 2) poor patient compliance, 3) drug side effects, and 4) concerns surrounding drug addiction.
The oncologists in the People's Republic of China simultaneously lack comprehensive knowledge and harbor misconceptions with regard to cancer pain treatment and morphine's clinical application. Creating professional training initiatives for oncologists is necessary to enhance their awareness and expertise in morphine use for cancer pain treatment.
调查中国肿瘤医师对癌痛和吗啡临床应用的认知情况，并分析目前影响吗啡临床应用的负面因素。
采用问卷调查的方式，对天津市肿瘤医院 150 名肿瘤医师进行随机抽样调查。采用 SPSS 21.0 和 Matlab 2012a 统计软件进行统计分析，采用单因素方差分析、Kruskal-Wallis 非参数检验、独立样本 t 检验分析吗啡使用知识得分的差异，找出影响吗啡临床应用的主要障碍因素。
在 127 名有效答卷者中，76 名（35.8%）医师选择吗啡控释片治疗重度癌痛；接受过癌痛管理及药物使用培训的医师基础知识评分显著高于未接受培训的医师（11.51±2.60 比 9.28±3.68，t=2.48，P=0.022）。影响吗啡广泛用于癌痛治疗的主要障碍因素前 4 位分别是：医务人员癌痛止痛治疗和药物使用培训不足、患者顺应性差、药物不良反应、担心成瘾。
中国肿瘤医师对癌痛治疗和吗啡临床应用的认知不足，存在误区。需要为肿瘤医师开展专业培训，提高其对吗啡治疗癌痛的认知和应用水平。
