Twa Michael D, Li Jiasong, Vantipalli Srilatha, Singh Manmohan, Aglyamov Salavat, Emelianov Stanislav, Larin Kirill V
University of Houston, College of Optometry, 505 J. Davis Armistead Building, Houston, Texas 77204-2020, USA ; University of Houston, Department of Biomedical Engineering, 4800 Calhoun Road, Houston, Texas 77004, USA.
University of Houston, Department of Biomedical Engineering, 4800 Calhoun Road, Houston, Texas 77004, USA.
Biomed Opt Express. 2014 Apr 4;5(5):1419-27. doi: 10.1364/BOE.5.001419. eCollection 2014 May 1.
Corneal collagen cross-linking (CXL) is a clinical treatment for keratoconus that structurally reinforces degenerating ocular tissue, thereby limiting disease progression. Clinical outcomes would benefit from noninvasive methods to assess tissue material properties in affected individuals. Regional variations in tissue properties were quantified before and after CXL in rabbit eyes using optical coherence elastography (OCE) imaging. Low-amplitude (<1µm) elastic waves were generated using micro air-pulse stimulation and the resulting wave amplitude and speed were measured using phase-stabilized swept-source OCE. OCE imaging following CXL treatment demonstrates increased corneal stiffness through faster elastic wave propagation speeds and lower wave amplitudes.
角膜交联（CXL）是一种用于圆锥角膜的临床治疗方法，它通过结构上增强退化的眼部组织来限制疾病进展。无创方法评估受影响个体的组织材料特性将有益于临床结果。使用光学相干弹性成像（OCE）对兔眼在CXL治疗前后的组织特性区域差异进行了量化。通过微空气脉冲刺激产生低振幅（<1µm）弹性波，并使用相位稳定扫频源OCE测量产生的波幅和波速。CXL治疗后的OCE成像显示，弹性波传播速度加快和波幅降低，角膜硬度增加。
