Razani Marjan, Mariampillai Adrian, Sun Cuiru, Luk Timothy W H, Yang Victor X D, Kolios Michael C
Biomed Opt Express. 2012 May 1;3(5):972-80. doi: 10.1364/BOE.3.000972. Epub 2012 Apr 16.
In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) based on a swept-source optical coherence tomography (OCT) system. Shear waves were generated using a 20 MHz piezoelectric transducer (circular element 8.5 mm diameter) transmitting sine-wave bursts of 400 μs, synchronized with the OCT swept source wavelength sweep. The acoustic radiation force (ARF) was applied to two gelatin phantoms (differing in gelatin concentration by weight, 8% vs. 14%). Differential OCT phase maps, measured with and without the ARF, demonstrate microscopic displacement generated by shear wave propagation in these phantoms of different stiffness. We present preliminary results of OCT derived shear wave propagation velocity and modulus, and compare these results to rheometer measurements. The results demonstrate the feasibility of shear wave OCE (SW-OCE) for high-resolution microscopic homogeneous tissue mechanical property characterization.
在这项工作中，我们基于扫频光学相干断层扫描（OCT）系统，探索了使用光学相干弹性成像（OCE）测量剪切波传播的潜力。使用一个20 MHz的压电换能器（直径8.5 mm的圆形元件）产生剪切波，该换能器发射400 μs的正弦波脉冲串，并与OCT扫频光源的波长扫描同步。将声辐射力（ARF）施加到两个明胶模型（按重量计明胶浓度不同，分别为8%和14%）上。在施加和不施加ARF的情况下测量的差分OCT相位图，展示了在这些不同刚度模型中由剪切波传播产生的微观位移。我们给出了由OCT得出的剪切波传播速度和模量的初步结果，并将这些结果与流变仪测量结果进行比较。结果证明了剪切波OCE（SW - OCE）用于高分辨率微观均匀组织力学性能表征的可行性。
