中国男男性行为者中的艾滋病毒发病率及危险因素——一项前瞻性队列研究
HIV incidence and risk factors in Chinese young men who have sex with men--a prospective cohort study.
作者信息
Dong Zhenxin, Xu Jie, Zhang Hongbo, Dou Zhi, Mi Guodong, Ruan Yuhua, Shen Limei, Min Xiangdong, Lan Guanghua, Li Fan, Li Tian, Ning Zhen, Wu Guohui, She Min, Wu Zunyou
机构信息
School of Public Health, Anhui Medical University, Hefei, Anhui Province, China.
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
出版信息
PLoS One. 2014 May 30;9(5):e97527. doi: 10.1371/journal.pone.0097527. eCollection 2014.
OBJECTIVES
To assess HIV incidence and its associated risk factors among young men who have sex with men (YMSM) in urban areas, China.
DESIGN
The study used a prospective cohort study design and standard diagnostic tests.
METHODS
A twelve-month prospective cohort study was conducted among YMSM (18-25 years old) in 8 large cities in China. The participants were recruited via snowball sampling. A total of 1102 HIV-negative YMSM completed baseline assessment, 878 YMSM participants completed 6-month follow-up, and 902 completed 12-month follow-up. HIV was screened by an enzyme-linked immunosorbent assay and confirmed with Western Blot. Syphilis was screened via rapid plasma reagent and confirmed by treponema pallidum particle agglutination assay.
RESULTS
78 HIV seroconversions were identified within 1168.4 person-year observations yielding an incidence rate of 6.7 per 100 person-years. HIV seroconversion was associated with non-student status (RR = 2.61, 90% CI = 1.3-5.26), low HIV transmission knowledge (RR = 8.87, 90% CI = 2.16-36.43), and syphilis infection (RR = 5.04, 90% CI = 2.57-9.90).
CONCLUSIONS
Incidence of HIV among YMSM is high in urban areas of China. Interventions measures are required to contain the HIV epidemic within this population.
目的
评估中国城市地区男男性行为者（YMSM）中的艾滋病毒感染率及其相关危险因素。
设计
本研究采用前瞻性队列研究设计和标准诊断测试。
方法
在中国8个大城市对18至25岁的男男性行为者进行了为期12个月的前瞻性队列研究。参与者通过滚雪球抽样招募。共有1102名艾滋病毒阴性的男男性行为者完成了基线评估，878名参与者完成了6个月的随访，902名完成了12个月的随访。通过酶联免疫吸附试验筛查艾滋病毒，并用蛋白质印迹法进行确认。通过快速血浆反应素试剂筛查梅毒，并用梅毒螺旋体颗粒凝集试验进行确认。
结果
在1168.4人年的观察期内发现了78例艾滋病毒血清阳转，发病率为每100人年6.7例。艾滋病毒血清阳转与非学生身份（RR = 2.61，90%CI = 1.3 - 5.26）、艾滋病毒传播知识水平低（RR = 8.87，90%CI = 2.16 - 36.43）以及梅毒感染（RR = 5.04，90%CI = 2.57 - 9.90）有关。
结论
中国城市地区男男性行为者中的艾滋病毒感染率很高。需要采取干预措施来控制该人群中的艾滋病毒疫情。
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