适应性免疫反应中的干扰素调节因子3
Interferon regulatory factor 3 in adaptive immune responses.
作者信息
Ysebrant de Lendonck Laure, Martinet Valerie, Goriely Stanislas
机构信息
WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles, 8 rue Adrienne Bolland, 6041, Charleroi-Gosselies, Belgium.
出版信息
Cell Mol Life Sci. 2014 Oct;71(20):3873-83. doi: 10.1007/s00018-014-1653-9. Epub 2014 May 31.
Abstract
Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells. Recent evidences indicate that this pathway also modulates adaptive immune responses. This review focuses on the different mechanisms that are implicated in this process. We discuss the role of IRF3 within antigen-presenting cells and T lymphocytes in the polarization of the cellular immune response and its implication in the pathogenesis of immune disorders.
摘要
干扰素调节因子（IRF）3在针对病毒的先天性免疫反应中起关键作用。事实上，这种转录因子的激活会触发受感染细胞中I型干扰素和下游干扰素刺激基因的表达。最近的证据表明，该途径也调节适应性免疫反应。本综述重点关注这一过程中涉及的不同机制。我们讨论了IRF3在抗原呈递细胞和T淋巴细胞中在细胞免疫反应极化中的作用及其在免疫紊乱发病机制中的意义。
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