抑素表达失调与胃癌的 3' 非翻译区 1630 C>T 多态性和拷贝数变异有关。
Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation.
机构信息
Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Departamento de Ortopedia e Traumatologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Laboratório de Oncologia Experimental, Departamento de Radiologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil; Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil.
出版信息
PLoS One. 2014 May 30;9(5):e98583. doi: 10.1371/journal.pone.0098583. eCollection 2014.
PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.
PHB 是胃癌中报道的癌基因和肿瘤抑制因子。在这里，我们评估了 PHB 拷贝数和 rs6917 多态性是否影响其在胃癌中的表达。在评估的肿瘤中观察到 PHB 的下调和上调。表达降低与肿瘤去分化和癌症起始有关。rs6917 多态性的 T 等位基因与 PHB mRNA 水平降低有关。此外，PHB 的上调似乎受到额外基因拷贝数增加的调节。因此，PHB 拷贝数变异和 rs6917 多态性的差异表达可能在 PHB 转录调控中发挥作用。
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