Huang Hui, Jiang Chun, Feng ZhenZhou, Jiang Xiaoxing
Department of Orthopedics Surgery, Shanghai Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Eur Spine J. 2014 Oct;23(10):2068-74. doi: 10.1007/s00586-014-3388-6. Epub 2014 May 31.
A self-control study was designed to compare the process of creeping substitution between allograft bone and local bone grafting in lumbar interbody fusion.
From December 2011 to July 2012, 81 patients (mean age: 56.4) were included in this study and randomly allocated to two groups. Leopard cages were using in unilateral instrumentation transforaminal lumbar interbody fusion. In group 1, the cages were filled with the local bone on the side of the instrumentation and allograft bone on the other side. In group 2, they were totally filled with the local bone chips. Then, the special CT-reconstructions were made at 6- and 12-month follow-up. On the sagittal section, the sections of CT-reconstructions were perpendicular to the lateral axis of the cage from the side of the cage to the other side. Similarly, they were parallel to the lateral axis of the cage on the coronal section and intervertebral space on the cross section. The mean area size of bone mass on both sides of the cage was calculated, respectively, using image analysis software (Osirix, version 3.3.2) on each section in two groups.
In group 1, at 6- and 12-month follow-up, significant differences were observed in the mean area size of bone mass between allograft bone and local bone grafting on the coronal, cross, and sagittal section. In group 2, the mean area size of local bone on both sides of the cage had no significant differences at 6- and 12-month follow-up on each section.
The results of our study showed a superiority of local bone grafting over allograft bone.
设计一项自身对照研究，比较同种异体骨与局部植骨在腰椎椎间融合术中爬行替代的过程。
2011年12月至2012年7月，81例患者（平均年龄：56.4岁）纳入本研究并随机分为两组。在单侧器械辅助经椎间孔腰椎椎间融合术中使用Leopard椎间融合器。第1组，椎间融合器一侧填充器械侧的局部骨，另一侧填充同种异体骨。第2组，椎间融合器完全填充局部骨块。然后，在随访6个月和12个月时进行特殊的CT重建。在矢状面上，CT重建的切片从椎间融合器一侧到另一侧垂直于椎间融合器的横轴。同样，在冠状面上它们平行于椎间融合器的横轴，在横断面上平行于椎间隙。使用图像分析软件（Osirix，版本3.3.2）分别计算两组各切片上椎间融合器两侧骨量的平均面积大小。
在第1组，随访6个月和12个月时，在冠状面、横断面和矢状面上，同种异体骨与局部植骨之间骨量的平均面积大小存在显著差异。在第2组，随访6个月和12个月时，椎间融合器两侧局部骨的平均面积大小在各切片上均无显著差异。
我们的研究结果显示局部植骨优于同种异体骨。
