Yuan Ti-Fei, Slotnick Burton M
School of Psychology, Nanjing Normal University, China.
Department of Psychology, American University, United States.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:26-30. doi: 10.1016/j.pnpbp.2014.05.013. Epub 2014 May 29.
The olfactory system is involved in sensory functions, emotional regulation and memory formation. Olfactory bulbectomy in rat has been employed as an animal model of depression for antidepressant discovery studies for many years. Olfaction is impaired in animals suffering from chronic stress, and patients with clinical depression were reported to have decreased olfactory function. It is believed that the neurobiological bases of depression might include dysfunction in the olfactory system. Further, brain stimulation, including nasal based drug delivery could provide novel therapies for management of depression.
嗅觉系统参与感觉功能、情绪调节和记忆形成。多年来，大鼠嗅球切除术已被用作抑郁症动物模型以进行抗抑郁药发现研究。患有慢性应激的动物嗅觉受损，据报道临床抑郁症患者嗅觉功能下降。人们认为抑郁症的神经生物学基础可能包括嗅觉系统功能障碍。此外，包括经鼻给药在内的脑刺激可为抑郁症的治疗提供新的疗法。
