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嗅觉丧失对生活质量的影响:2025年综述

The Impact of Olfactory Loss on Quality of Life: A 2025 Review.

作者信息

Oleszkiewicz Anna, Croy Ilona, Hummel Thomas

机构信息

Interdisciplinary Center Smell & Taste, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden.

Institute of Psychology, University of Wroclaw.

出版信息

Chem Senses. 2025 Jul 25;50. doi: 10.1093/chemse/bjaf023.

DOI:10.1093/chemse/bjaf023
PMID:40719006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12302507/
Abstract

For a long time, the sense of smell was considered the neglected stepbrother of human sensory abilities, and the loss of smell has received little attention. This perception changed dramatically with the COVID-19 pandemic, which led to millions of people losing their sense of smell, and some never recovering. COVID-19 not only increased general awareness of olfactory disorders but also accelerated research into the role of smell in nonverbal communication and mental health. This review aims to summarize the literature on the impact of olfactory disorders on quality of life. Starting from the functions of olfaction in healthy individuals, we will briefly describe the most common olfactory disorders and their effect on an individual's life, including nutrition and eating behaviors, social and psychological well-being, and exposure to environmental hazards. Consequences of olfactory loss permeate many spheres of daily life. On average, dysosmia has a moderate impact on quality of life, though for some patients the effects can be severe.

摘要

长期以来,嗅觉一直被视为人类感官能力中被忽视的“小兄弟”,嗅觉丧失很少受到关注。随着新冠疫情的爆发,这种观念发生了巨大变化,疫情导致数百万人失去嗅觉,有些人再也无法恢复。新冠疫情不仅提高了人们对嗅觉障碍的普遍认识,还加速了对嗅觉在非语言交流和心理健康中作用的研究。本综述旨在总结关于嗅觉障碍对生活质量影响的文献。从健康个体的嗅觉功能出发,我们将简要描述最常见的嗅觉障碍及其对个人生活的影响,包括营养和饮食行为、社会和心理健康,以及接触环境危害。嗅觉丧失的后果渗透到日常生活的许多领域。平均而言,嗅觉障碍对生活质量有中度影响,不过对一些患者来说,影响可能很严重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1685/12302507/3b0e34d98dbd/bjaf023_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1685/12302507/00708db3dab7/bjaf023_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1685/12302507/3b0e34d98dbd/bjaf023_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1685/12302507/00708db3dab7/bjaf023_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1685/12302507/3b0e34d98dbd/bjaf023_fig2.jpg

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本文引用的文献

1
Olfactory Deficits and Mortality in Older Adults.老年人的嗅觉缺陷与死亡率
JAMA Otolaryngol Head Neck Surg. 2025 Apr 10. doi: 10.1001/jamaoto.2025.0174.
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The impact of COVID-19-related smell dysfunction on sexual and mental wellbeing: Data from a longitudinal sample.新冠病毒相关嗅觉功能障碍对性健康和心理健康的影响:来自纵向样本的数据
Biol Psychol. 2025 Feb;195:109002. doi: 10.1016/j.biopsycho.2025.109002. Epub 2025 Feb 16.
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Olfactory Dysfunction in Children and Adolescents-A Diagnostic Pathway.儿童和青少年的嗅觉功能障碍——一种诊断途径
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Cognitive behavioural therapy versus other interventions on mental health in people with sensory impairments: A systematic review and meta-analysis.认知行为疗法与其他干预措施对感觉障碍患者心理健康的影响:一项系统评价与荟萃分析
J Psychosom Res. 2025 Feb;189:111998. doi: 10.1016/j.jpsychores.2024.111998. Epub 2024 Nov 30.
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Humans without a sense of smell breathe differently.人没有嗅觉时呼吸方式不同。
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Changes in weight secondary to improved odor perception in chronic rhinosinusitis with nasal polyps' patients treated with Dupilumab.接受度普利尤单抗治疗的伴有鼻息肉的慢性鼻-鼻窦炎患者因嗅觉改善继发的体重变化。
Eur Arch Otorhinolaryngol. 2025 Jan;282(1):251-256. doi: 10.1007/s00405-024-09021-0. Epub 2024 Oct 15.
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Using Cooking Schools to Improve the Pleasure of Food and Cooking in Patients Experiencing Smell Loss.利用烹饪学校提升嗅觉丧失患者对食物和烹饪的乐趣。
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Long-term olfactory loss post-COVID-19: Pathobiology and potential therapeutic strategies.新冠病毒感染后长期嗅觉丧失:病理生物学及潜在治疗策略
World J Otorhinolaryngol Head Neck Surg. 2024 Mar 21;10(2):148-155. doi: 10.1002/wjo2.165. eCollection 2024 Jun.