Vítovec J, Pakandl M
Institute of Parasitology, Czechoslovak Academy of Sciences.
Folia Parasitol (Praha). 1989;36(4):289-93.
The pathogenicity of Eimeria coecicola for rabbits has been demonstrated in our experiments. The animals suffered from prolonged affection of appendix lasting at least 20 days. Pathological changes appeared with the development of merogony since day 4 post infection (DPI) and were characterized by an inflammatory infiltration and abundant pyogenic component in lamina propria, swelling and coalescence of upper parts of appendix mucosa above atrophied domes, where spaces filled with stagnating inflammatory exudate, endogenic stages of coccidia, and desquamated epithelia are formed. The alteration of the epithelium and exposure of the appendix lamina propria occur in relation with the gametogony in the period of about 10 DPI. Since 8 DPI, the epithelium of the infected endogenic stages of coccidia becomes hyperplastic, proliferates into lamina propria and is subjected to necrosis. Groups of immature oocysts and their fragments remain in lamina propria and are resorbed, at least for 10 days, by granulomatous inflammatory structures with abundant multinucleate cells of the type of foreign body cells.
在我们的实验中已证实盲肠艾美耳球虫对家兔具有致病性。动物患盲肠炎的时间延长，至少持续20天。自感染后第4天（dpi）开始，随着裂殖生殖的发展出现病理变化，其特征为固有层有炎性浸润和大量化脓成分，萎缩圆顶上方的盲肠黏膜上部肿胀并融合，形成充满停滞炎性渗出物、球虫内生阶段和脱落上皮的间隙。在大约10 dpi时，上皮的改变和盲肠固有层的暴露与配子生殖有关。自8 dpi起，受感染的球虫内生阶段的上皮细胞增生，向固有层增殖并发生坏死。未成熟卵囊及其碎片团块留在固有层，至少在10天内被含有大量异物细胞类型的多核细胞的肉芽肿性炎症结构吸收。
