Zuo Hai-Ning, Wang Zhi-Long, Cui Dao-Ran, Xin Da-Jiang
1st Department of Trauma Surgery, Yantai Hill Hospital of Yantai, Yantai, 264000, People's Republic of China.
Mol Biol Rep. 2014 Aug;41(8):5311-9. doi: 10.1007/s11033-014-3402-4. Epub 2014 Jun 1.
The present meta-analysis of relevant case-control studies was conducted to investigate the possible relationships between genetic variations in the killer cell immunoglobulin-like receptor (KIR) gene clusters of the human KIR gene family and susceptibility to ankylosing spondylitis (AS). The following electronic databases were searched for relevant articles without language restrictions: the Web of Science, the Cochrane Library Database, PubMed, EMBASE, CINAHL, the Chinese Biomedical Database (CBM) and Chinese National Knowledge Infrastructure (CNKI) databases, covering all papers published until 2013. STATA statistical software was adopted in this meta-analysis as well. We also calculated the crude odds ratios (OR) and its 95% confidence intervals (95 % CI). Seven case-control studies with 1,004 patients diagnosed with AS and 2,138 healthy cases were implicated in our meta-analysis, and 15 genes in the KIR gene family were also evaluated. The results of our meta-analysis show statistical significance between the genetic variations in the KIR2DL1, KIR2DS4, KIR2DS5 and KIR3DS1 genes and an increased susceptibility to AS (KIR2DL1: OR 7.82, 95% CI 3.87-15.81, P< 0.001; KIR2DS4: OR 1.91, 95% CI 1.16-3.13, P = 0.010; KIR2DS5: OR1.51, 95% CI 1.14-2.01, P = 0.004; KIR3DS1: OR 1.58, 95% CI 1.34-1.86, P< 0.001; respectively). However, we failed to found positive correlations between other genes and susceptibility to AS (all P >0.05). The current meta-analysis provides reliable evidence that genetic variations in the KIR gene family may contribute to susceptibility to AS, especially for the KIR2DL1, KIR2DS4, KIR2DS5 and KIR3DS1 genes.
本项针对相关病例对照研究的荟萃分析旨在调查人类杀伤细胞免疫球蛋白样受体（KIR）基因家族的KIR基因簇中的基因变异与强直性脊柱炎（AS）易感性之间的可能关系。我们检索了以下电子数据库中的相关文章，无语言限制：科学网、考克兰图书馆数据库、PubMed、EMBASE、护理学与健康领域数据库（CINAHL）、中国生物医学文献数据库（CBM）和中国知网数据库（CNKI），涵盖截至2013年发表的所有论文。本荟萃分析还采用了STATA统计软件。我们还计算了粗比值比（OR）及其95%置信区间（95%CI）。我们的荟萃分析纳入了7项病例对照研究，共1004例确诊为AS的患者和2138例健康对照，同时评估了KIR基因家族中的15个基因。我们的荟萃分析结果显示，KIR2DL1、KIR2DS4、KIR2DS5和KIR3DS1基因的基因变异与AS易感性增加之间存在统计学意义（KIR2DL1：OR 7.82，95%CI 3.87 - 15.81，P < 0.001；KIR2DS4：OR 1.91，95%CI 1.16 - 3.13，P = 0.010；KIR2DS5：OR 1.51，95%CI 1.14 - 2.01，P = 0.004；KIR3DS1：OR 1.58，95%CI 1.34 - 1.86，P < 0.001）。然而，我们未发现其他基因与AS易感性之间存在正相关（所有P > 0.05）。当前的荟萃分析提供了可靠的证据，表明KIR基因家族中的基因变异可能导致AS易感性增加，尤其是KIR2DL1、KIR2DS4、KIR2DS5和KIR3DS1基因。
