Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University School of Medicine, Chicago, IL.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University School of Medicine, Chicago, IL.
Am J Obstet Gynecol. 2014 Nov;211(5):494.e1-5. doi: 10.1016/j.ajog.2014.05.042. Epub 2014 May 29.
To compare live birth rates following ultrasound-guided embryo transfer (ET) by reproductive endocrinology and infertility fellows versus attending physicians.
Women who underwent their first day-3, fresh, nondonor ET between Oct. 1, 2005, and April 1, 2011, at our academic center were included in this retrospective cohort study. Embryos were designated high quality if they had 8 cells, less than 10% fragmentation, and no asymmetry. ET was performed with the afterload technique under ultrasound guidance. Categorical variables were evaluated with the χ(2) test and continuous variables with the Student t test. Logistic regression was performed to assess the relationship between ET physician and live birth rate while adjusting for potential confounders.
Seven hundred sixty women underwent ET by an attending physician, and 104 by a fellow. Baseline characteristics were similar between the groups. The live birth rate was 31% following ET by an attending physician, compared with 34% following ET by a fellow (P = .65). Logistic regression adjusting for potential confounders demonstrated no significant association between ET physician and live birth rate.
This retrospective study demonstrated no significant difference in live birth rates following ultrasound-guided ET by fellows vs attending physicians at our institution. These data suggest that academic practices using the afterload method and ultrasound guidance can train fellows to perform ET without compromising success rates.
比较超声引导胚胎移植(ET)由生殖内分泌学和不孕不育研究员与主治医生进行的活产率。
本回顾性队列研究纳入了 2005 年 10 月 1 日至 2011 年 4 月 1 日期间在我们学术中心进行首次第 3 天新鲜非供体 ET 的女性。胚胎被指定为高质量,如果它们有 8 个细胞,少于 10%的碎片,且没有不对称。ET 是在超声引导下进行的后负荷技术。分类变量采用卡方检验,连续变量采用 Student t 检验。采用逻辑回归评估 ET 医生与活产率之间的关系,同时调整潜在混杂因素。
760 名妇女由主治医生进行 ET,104 名妇女由研究员进行 ET。两组的基线特征相似。主治医生进行 ET 的活产率为 31%,而研究员进行 ET 的活产率为 34%(P =.65)。调整潜在混杂因素的逻辑回归显示,ET 医生与活产率之间无显著关联。
本回顾性研究表明,在我们机构,超声引导 ET 由研究员与主治医生进行时,活产率没有显著差异。这些数据表明,采用后负荷方法和超声引导的学术实践可以培训研究员进行 ET,而不会降低成功率。