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宫腔内人工授精作为生殖内分泌和不孕不育研究员培训项目中进行胚胎移植的训练方式的效果。

Efficacy of intrauterine inseminations as a training modality for performing embryo transfer in reproductive endocrinology and infertility fellowship programs.

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.

出版信息

Fertil Steril. 2013 Aug;100(2):386-91. doi: 10.1016/j.fertnstert.2013.03.035. Epub 2013 Apr 16.

Abstract

OBJECTIVE

To assess pregnancy rates before and after a training intervention in which reproductive endocrinology and infertility fellows were required to perform 100 IUIs before performing ETs.

DESIGN

Retrospective cohort study.

SETTING

Large, academic training program.

PATIENT(S): Not applicable.

INTERVENTION(S): Comparing pregnancy rates between two time periods: July 1998-June 2001 (before IUI intervention) and July 2001-June 2010 (after IUI intervention).

MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (PR) for the first 100 ETs performed by fellows before and after the IUI training; median attending physician PR during each time period served as the referent. Multivariate generalized estimating equations were used to calculate odds of pregnancy per ET for fellows as compared with attending physicians.

RESULT(S): Multivariate analyses revealed no significant difference in PR for the first 100 ETs performed by fellows as compared with attending physicians, before or after the IUI training requirement (odds ratio 0.99, 95% confidence interval 0.82-1.20 and odds ratio 0.91, 95% confidence interval 0.81-1.30, respectively). The median attending physician PR in the preintervention group was exceeded by fellows after the first 70 ETs; fellows in the postintervention group exceeded the median attending physician PR after 100 ETs. The PR in both groups improved as fellows progressed from the first 20 to 100 ETs.

CONCLUSION(S): The PR for the first 100 ETs performed by fellows was unchanged after implementing an IUI training requirement. The substantial variation noted among individual fellows decreased as more ETs were completed.

摘要

目的

评估生殖内分泌和不孕不育研究员在进行 ET 之前需要进行 100 次 IUI 后,培训干预前后的妊娠率。

设计

回顾性队列研究。

地点

大型学术培训计划。

患者

不适用。

干预

比较两个时间段的妊娠率:1998 年 7 月至 2001 年 6 月(IUI 干预前)和 2001 年 7 月至 2010 年 6 月(IUI 干预后)。

主要观察指标

研究员进行的前 100 次 ET 的临床妊娠率(PR),在 IUI 培训之前和之后;在每个时间段内,中位数主治医生 PR 作为参考。使用多变量广义估计方程计算研究员与主治医生相比,每次 ET 的妊娠几率。

结果

多变量分析显示,在 IUI 培训要求之前或之后,研究员进行的前 100 次 ET 的 PR 与主治医生相比没有显著差异(比值比 0.99,95%置信区间 0.82-1.20 和比值比 0.91,95%置信区间 0.81-1.30)。干预前组的中位数主治医生 PR 在进行前 70 次 ET 后被研究员超过;干预后组的研究员在进行 100 次 ET 后超过中位数主治医生 PR。随着研究员从第 20 次到第 100 次 ET 的进展,两组的 PR 都有所提高。

结论

实施 IUI 培训要求后,研究员进行的前 100 次 ET 的 PR 没有变化。随着更多 ET 的完成,研究员之间的显著差异有所减少。

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