Patounakis George, Ozcan Meghan C, Chason Rebecca J, Norian John M, Payson Mark, DeCherney Alan H, Yauger Belinda J
National Institutes of Health/National Institute of Child Health and Human Development, Bethesda, Maryland.
Walter Reed National Military Medical Center, Bethesda, Maryland.
Fertil Steril. 2016 Aug;106(2):311-6. doi: 10.1016/j.fertnstert.2016.03.045. Epub 2016 Apr 14.
To determine whether a history of prior cesarean delivery (CD) makes ET more difficult and impacts pregnancy outcomes.
Prospective cohort study.
Tertiary care military facility.
PATIENT(S): One hundred ninety-four patients with previous delivery undergoing IVF/intracytoplasmic sperm injection (ICSI)-ET.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Live birth (primary), positive hCG, clinical pregnancy, and time to perform ET.
RESULT(S): There was no statistically significant difference between patients with a history of only vaginal deliveries versus those with a history of CD for live birth (39% vs. 32%), positive hCG (56% vs. 53%), or clinical pregnancy (49% vs. 41%). Embryo transfers took longer in the history of CD group (157 vs. 187 seconds) and were more likely to have mucus (27% vs. 45%) or blood (8% vs. 21%) on the catheter.
CONCLUSION(S): Embryo transfers performed on patients with a prior CD took 30 seconds longer. They were also more likely to have blood or mucus on the catheter. Despite the apparently more difficult transfers, pregnancy outcomes were not different between the two groups.
确定既往剖宫产史是否会使胚胎移植(ET)更加困难并影响妊娠结局。
前瞻性队列研究。
三级医疗军事机构。
194例既往有分娩史且正在接受体外受精/卵胞浆内单精子注射(ICSI)-ET的患者。
无。
活产(主要指标)、人绒毛膜促性腺激素(hCG)阳性、临床妊娠以及进行ET的时间。
仅有阴道分娩史的患者与有剖宫产史的患者在活产率(39%对32%)、hCG阳性率(56%对53%)或临床妊娠率(49%对41%)方面无统计学显著差异。有剖宫产史的组进行胚胎移植所需时间更长(157秒对187秒),并且导管上更有可能出现黏液(27%对45%)或血液(8%对21%)。
有既往剖宫产史的患者进行胚胎移植的时间要长30秒。导管上出现血液或黏液的可能性也更大。尽管移植过程明显更困难,但两组的妊娠结局并无差异。