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聚乙烯亚胺纳米颗粒的抗菌效果与树脂复合材料中颗粒分布的关系表征

Characterisation of the antibacterial effect of polyethyleneimine nanoparticles in relation to particle distribution in resin composite.

作者信息

Shvero Dana Kesler, Zatlsman Nathan, Hazan Ronen, Weiss Ervin I, Beyth Nurit

机构信息

Department of Prosthodontics, Faculty of Dentistry, The Hebrew University - Hadassah, Jerusalem, Israel.

Department of Prosthodontics, Faculty of Dentistry, The Hebrew University - Hadassah, Jerusalem, Israel.

出版信息

J Dent. 2015 Feb;43(2):287-94. doi: 10.1016/j.jdent.2014.05.003. Epub 2014 May 29.

Abstract

OBJECTIVES

To characterise the antibacterial effect of resin composite incorporating cross-linked quaternised polyethyleneimine (QPEI) nanoparticles in relation to their distribution in the bulk material.

METHODS

The antibacterial effect of resin composite incorporating QPEI nanoparticle was tested against various oral pathogens, including Enterococcus faecalis, Streptococcus mutans, Actinomyces viscousus, Lactobacilus casei and whole saliva. Nanoparticle distribution in the modified resin composite was assessed using X-ray photoelectron spectroscopy (XPS). Additionally, the degree of conversion was recorded.

RESULTS

Total bacterial inhibition was detected against all the tested pathogens following direct contact with the outer surface of the modified resin composite. Similarly, the inner surface of the modified resin composite caused total inhibition. Electron microscope images showed bacterial death. XPS revealed surface I(-) ions on both the outer and the inner surfaces of the modified composite. No I(-) ions were detected in the unmodified composite. Nanoparticle distribution was higher on the inner surface of the modified composite. The composite's degree of conversion was unaffected by nanoparticle addition.

CONCLUSIONS

QPEI nanoparticles represent a new generation of antibacterial nanoparticles which are highly promising in preventing bacterial recontamination when restoring teeth.

摘要

目的

表征含有交联季铵化聚乙烯亚胺(QPEI)纳米颗粒的树脂复合材料的抗菌效果及其在块状材料中的分布情况。

方法

测试了含有QPEI纳米颗粒的树脂复合材料对多种口腔病原体的抗菌效果,这些病原体包括粪肠球菌、变形链球菌、黏性放线菌、干酪乳杆菌和全唾液。使用X射线光电子能谱(XPS)评估纳米颗粒在改性树脂复合材料中的分布。此外,记录转化率。

结果

与改性树脂复合材料外表面直接接触后,对所有测试病原体均检测到完全细菌抑制。同样,改性树脂复合材料的内表面也导致完全抑制。电子显微镜图像显示细菌死亡。XPS显示改性复合材料外表面和内表面均有表面I(-)离子。未改性复合材料中未检测到I(-)离子。纳米颗粒在改性复合材料内表面的分布更高。纳米颗粒的添加未影响复合材料的转化率。

结论

QPEI纳米颗粒代表了新一代抗菌纳米颗粒,在牙齿修复时预防细菌再污染方面极具前景。

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