Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143, USA.
Clin Oral Investig. 2021 Sep;25(9):5293-5305. doi: 10.1007/s00784-021-03837-4. Epub 2021 Feb 19.
To investigate whether a newly developed dental composite with quaternary ammonium silica dioxide (QASi) nanoparticles incorporated with other fillers into the restorative material demonstrates antibacterial activity by reducing enamel demineralization in an in situ gap model.
Twenty subjects wearing a lower removable partial denture (RPD) with acrylic flanges on both sides of the mouth were recruited into the 4-week in situ study. The gap model consisted of an enamel slab placed next to a composite, separated by a 38-μm space. In the split-mouth design on one side of the RPD, the composite was the Nobio Infinix composite (Nobio Ltd., Kadima, Israel), and the contralateral side used a control composite. Each participant received enamel slabs from one tooth. The gap model was recessed into the RPD buccal flange, allowing microbial plaque to accumulate within the gap. After 4 weeks of continuous wearing, decalcification (∆Z mineral loss) of the enamel slabs adjacent to the gap was determined by cross-sectional microhardness testing in the laboratory.
The ∆Z for the antibacterial composite test side was 235±354 (mean±standard deviation [SD]; data reported from 17 participants) and statistically significantly lower compared to ∆Z of the control side (774±556; mean±SD) (paired t-test, P<0.0001; mean of test minus control -539 (SD=392), 95% confidence interval of difference: -741, -338).
This in situ clinical study showed that composites with QASi antibacterial particles significantly reduced demineralization in enamel adjacent to a 38-μm gap over a 4-week period in comparison to a conventional composite.
Composites with QASi nanoparticle technology have the potential to reduce the occurrence of secondary caries.
ClinicalTrials.gov #NCT04059250.
研究一种新开发的牙科复合材料，该复合材料将季铵硅二氧化硅（QASi）纳米粒子与其他填料结合到修复材料中，通过减少在原位间隙模型中牙釉质脱矿来证明其抗菌活性。
20 名佩戴下颌可摘局部义齿（RPD）的受试者，义齿两侧均有丙烯酸法兰，被纳入为期 4 周的原位研究。间隙模型由放置在复合材料旁边的牙釉质平板组成，两者之间的间隔为 38μm。在 RPD 一侧的分口设计中，复合材料为 Nobio Infinix 复合材料（以色列 Kadima 的 Nobio Ltd.），而对侧使用对照复合材料。每位参与者从一颗牙齿获得牙釉质平板。间隙模型被凹入 RPD 颊侧法兰内，允许微生物菌斑在间隙内积聚。经过 4 周的连续佩戴后，通过实验室横截面显微硬度测试来确定与间隙相邻的牙釉质平板的脱矿（∆Z 矿物质损失）。
抗菌复合测试侧的 ∆Z 为 235±354（平均值±标准偏差 [SD]；来自 17 名参与者的数据），与对照侧的 ∆Z（774±556；平均值±SD）相比，统计学上显著降低（配对 t 检验，P<0.0001；测试减去对照的平均值为-539（SD=392），差值的 95%置信区间：-741，-338）。
这项原位临床研究表明，与传统复合材料相比，在 4 周内，具有 QASi 抗菌颗粒的复合材料显著减少了 38μm 间隙附近牙釉质的脱矿。
具有 QASi 纳米技术的复合材料具有减少继发龋发生的潜力。
ClinicalTrials.gov #NCT04059250。
