Ferrando-Magraner Elena, Bellot-Arcís Carlos, Paredes-Gallardo Vanessa, Almerich-Silla José Manuel, García-Sanz Verónica, Fernández-Alonso Mercedes, Montiel-Company José María
Orthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.
Preventive Dentistry Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.
Medicina (Kaunas). 2020 Jan 29;56(2):55. doi: 10.3390/medicina56020055.
Nanotechnology has become a significant area of research focused mainly on increasing the antibacterial and mechanical properties of dental materials. The aim of the present systematic review and meta-analysis was to examine and quantitatively analyze the current evidence for the addition of different nanoparticles into dental restorative materials, to determine whether their incorporation increases the antibacterial/antimicrobial properties of the materials. A literature search was performed in the Pubmed, Scopus, and Embase databases, up to December 2018, following PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines for systematic reviews and meta-analyses. A total of 624 papers were identified in the initial search. After screening the texts and applying inclusion criteria, only 11 of these were selected for quantitative analysis. The incorporation of nanoparticles led to a significant increase (p-value <0.01) in the antibacterial capacity of all the dental materials synthesized in comparison with control materials. The incorporation of nanoparticles into dental restorative materials was a favorable option; the antibacterial activity of nanoparticle-modified dental materials was significantly higher compared with the original unmodified materials, TiO nanoparticles providing the greatest benefits. However, the high heterogeneity among the articles reviewed points to the need for further research and the application of standardized research protocols.
纳米技术已成为一个重要的研究领域，主要聚焦于提高牙科材料的抗菌性能和机械性能。本系统评价和荟萃分析的目的是检查并定量分析将不同纳米颗粒添加到牙科修复材料中的现有证据，以确定其加入是否能增强材料的抗菌性能。按照系统评价和荟萃分析的PRISMA（系统评价和荟萃分析的首选报告项目）指南，于2018年12月前在PubMed、Scopus和Embase数据库中进行了文献检索。在初步检索中总共识别出624篇论文。在筛选文本并应用纳入标准后，仅选择了其中11篇进行定量分析。与对照材料相比，纳米颗粒的加入使所有合成牙科材料的抗菌能力显著提高（p值<0.01）。将纳米颗粒加入牙科修复材料是一个不错的选择；与原始未改性材料相比，纳米颗粒改性牙科材料的抗菌活性显著更高，其中TiO纳米颗粒带来的益处最大。然而，所审查文章之间的高度异质性表明需要进一步研究并应用标准化的研究方案。
