Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan ; Kishida Clinic, Toyonaka, Osaka, Japan.
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Diabetol Metab Syndr. 2014 May 27;6:64. doi: 10.1186/1758-5996-6-64. eCollection 2014.
Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with coronary artery disease (CAD). We recently reported that adiponectin binds to C1q in human blood, and serum C1q-binding adiponectin (C1q-APN) /Total-APN levels are associated with CAD in type 2 diabetic subjects. The present study investigated the relationship between circulating C1q-APN levels and the number of angiographic coronary artery vessel in male subjects.
The study subjects were 53 male Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), high-molecular weight adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays.
Serum C1q-APN/Total-APN ratio significantly increased in subjects with single and multi-vessel coronary diseases (p = 0.029 for trend, the Kruskal-Wallis test). However, serum Total-APN, HMW-APN, C1q-APN and C1q levels did not correlate with number of diseased coronary vessels.
Serum C1q-APN/Total-APN ratio progressively increases in men with single and multi-vessel coronary disease.
UMIN000002997.
脂联素在稳定动脉粥样硬化斑块方面发挥积极作用。循环总脂联素（Total-APN）水平与冠心病（CAD）男性患者冠状动脉血管数量有关。我们最近报道，脂联素在人血液中与 C1q 结合，血清 C1q 结合脂联素（C1q-APN）/总脂联素（Total-APN）水平与 2 型糖尿病患者的 CAD 相关。本研究探讨了循环 C1q-APN 水平与男性患者血管造影冠状动脉血管数量之间的关系。
本研究对象为 53 名接受诊断性冠状动脉造影的日本男性患者。通过酶联免疫吸附试验测定血液总脂联素（Total-APN）、高分子量脂联素（HMW-APN）、C1q-APN 和 C1q。
单支和多支病变冠状动脉疾病患者血清 C1q-APN/Total-APN 比值显著升高（Kruskal-Wallis 检验趋势，p=0.029）。然而，血清 Total-APN、HMW-APN、C1q-APN 和 C1q 水平与病变冠状动脉血管数量无关。
患有单支和多支病变冠状动脉疾病的男性患者血清 C1q-APN/Total-APN 比值逐渐升高。
UMIN000002997。
