Hong Eun Shil, Lim Cheong, Choi Hye Yeon, Ku Eu Jeong, Kim Kyoung Min, Moon Jae Hoon, Lim Soo, Park Kyong Soo, Jang Hak Chul, Choi Sung Hee
Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam, 463-707, South Korea.
Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea.
Cardiovasc Diabetol. 2015 May 9;14:50. doi: 10.1186/s12933-015-0209-0.
The complement component C1q triggers activation of the classical immune pathway and can bind to adiponectin (APN). Recently, some studies have been reported that serum C1q-APN/total APN ratio correlates with atherosclerosis and coronary artery disease (CAD). We assessed the relationships between C1q related variables and the severity of CAD, and investigated the localization of the C1q-APN complex.
The sample included 153 subjects comprising healthy controls and patients with subclinical or overt CAD. We measured the serum concentrations of C1q, total APN, and high-molecular weight (HMW)-APN, and the amount of C1q-APN complex. We identified the sites of C1q-APN complex deposition in various adipose tissues and blood vessels.
Serum concentrations of C1q and HMW-APN and the C1q/HMW-APN ratio were independently associated with the severity of coronary stenosis. The amount of C1q-APN complex was significantly higher in patients with CAD compared with controls. C1q and APN co-localized in perivascular areas of subcutaneous, visceral, and pericardial fat tissues, and the internal mammary artery of patients with severe CAD.
Serum C1q concentration and the C1q/HMW-APN ratio were independent markers of coronary artery stenosis. The amount of C1q-APN complex was significantly greater in serum from CAD patients. C1q and APN co-localized to perivascular areas in adipose tissue and blood vessels. The association between the increased amount of the C1q-APN complex and CAD should be investigated further.
补体成分C1q触发经典免疫途径的激活，并可与脂联素（APN）结合。最近，一些研究报道血清C1q-APN/总APN比值与动脉粥样硬化和冠状动脉疾病（CAD）相关。我们评估了C1q相关变量与CAD严重程度之间的关系，并研究了C1q-APN复合物的定位。
样本包括153名受试者，包括健康对照者以及亚临床或显性CAD患者。我们测量了血清C1q、总APN和高分子量（HMW）-APN的浓度，以及C1q-APN复合物的量。我们确定了C1q-APN复合物在各种脂肪组织和血管中的沉积部位。
血清C1q和HMW-APN浓度以及C1q/HMW-APN比值与冠状动脉狭窄的严重程度独立相关。与对照组相比，CAD患者的C1q-APN复合物量显著更高。在重度CAD患者的皮下、内脏和心包脂肪组织的血管周围区域以及乳内动脉中，C1q和APN共定位。
血清C1q浓度和C1q/HMW-APN比值是冠状动脉狭窄的独立标志物。CAD患者血清中的C1q-APN复合物量显著更高。C1q和APN在脂肪组织和血管的血管周围区域共定位。C1q-APN复合物量增加与CAD之间的关联应进一步研究。
