一种可调谐热敏多肽的双重响应性。
Dual responsiveness of a tunable thermo-sensitive polypeptide.
作者信息
Chopko Caroline M, Lowden Erika L, Engler Amanda C, Griffith Linda G, Hammond Paula T
机构信息
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Department of Biological Engineering, Department of Mechanical Engineering, and Center for Gynepathology Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
出版信息
ACS Macro Lett. 2012 Jun 19;1(6):727-731. doi: 10.1021/mz300088w.
Abstract
The temperature and pH dependent solubility of poly(γ-propargyl L-glutamate) (PPLG) functionalized through copper catalyzed 1,3 cycloaddition reaction between an alkyne and azide can be tuned with precision over a broad range of conditions by varying the ratio of substitution of short oligo ethylene glycol and diisopropylamine side groups.
摘要
通过炔烃与叠氮化物之间的铜催化1,3环加成反应功能化的聚（γ-炔丙基-L-谷氨酸）（PPLG），其温度和pH依赖性溶解度可通过改变短聚乙二醇和二异丙胺侧基的取代比例，在广泛的条件范围内进行精确调节。
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