Manchon N D, Bercoff E, Lemarchand P, Chassagne P, Senant J, Bourreille J
Clinique Médicale A, CHU de Rouen.
Rev Med Interne. 1989 Nov-Dec;10(6):521-5. doi: 10.1016/s0248-8663(89)80069-4.
The medicinal treatments of 639 patients aged over 65 were recorded on admission to hospital. The mean number of drugs consumed was 4.4 +/- 2.8 per patient. Drug interaction was found in 37 p. 100 of the patients on the basis of data published in the Vidal dictionary. The prevalence of interactions increased with the number of drugs prescribed. The medicinal families most frequently involved were digitalis derivatives, antiarrythmic agents, diuretics, anticoagulants and psychotropic drugs. Thirty patients (4.7 p. 100) presented with a side-effect that was directly ascribable to an interaction. Among the iatrogenic adverse reactions 11 were life-threatening, including 8 cases of severe dysrhythmia and 3 cases of gastrointestinal haemorrhages. Altogether, one-third of all iatrogenic disorders were consecutive to a drug interaction. Simple precautions would have considerably reduced the frequency of such side-effects.
对639名65岁以上患者入院时的药物治疗情况进行了记录。每位患者平均用药数量为4.4±2.8种。根据《维达尔词典》公布的数据，在100名患者中有37名被发现存在药物相互作用。药物相互作用的发生率随所开药物数量的增加而上升。最常涉及的药物类别是洋地黄衍生物、抗心律失常药、利尿剂、抗凝剂和精神药物。30名患者（占4.7%）出现了可直接归因于药物相互作用的副作用。在医源性不良反应中，11例危及生命，包括8例严重心律失常和3例胃肠道出血。总体而言，所有医源性疾病中有三分之一是由药物相互作用导致的。采取简单的预防措施本可大幅降低此类副作用的发生频率。
