一项关于南印度教学医院药物-药物相互作用的处方分析研究。
A study on drug-drug interactions through prescription analysis in a South Indian teaching hospital.
机构信息
JSS College of Pharmacy (A Constituent College of JSS University) Post Box No.20, Ooty - 643 001 Tamil Nadu, India.
JSS College of Pharmacy - Pharmacy Practice, Rocklands, Ooty, Tamil Nadu, India.
出版信息
Ther Adv Drug Saf. 2013 Aug;4(4):141-6. doi: 10.1177/2042098613490009.
OBJECTIVE
The objective of this study was to assess the drug-drug interactions (DDIs) through prescription analysis among the inpatients of a South Indian teaching hospital.
METHODS
The study was a prospective observational prescription analysis conducted for a period of 6 months, from October 2010 to March 2011. The prescriptions having two or more drugs and where a DDI was suspected were selected by the physician in charge of the ward. The drugs in the prescription were then entered into the drug interaction checker software. The DDIs were classified based on the mechanism of interactions, severity of interactions, relation to the number of drugs prescribed, and disease conditions were also determined.
RESULTS
A total of 204 prescriptions were analyzed, of which 186 prescriptions had 856 DDIs. Most of the DDIs were pharmacokinetic drug interactions (42%) followed by unknown mechanisms (34%) and pharmacodynamic mechanisms (24%). The study findings showed that the prescriptions for cardiovascular with respiratory disease conditions had the greatest number of drug interactions on average. A severity assessment showed that majority of the DDIs were moderate (70%) followed by minor (28%). The study results showed that as the number of drugs increases in a prescription, the number of DDIs also increases. The interventions determined showed that dosage adjustment (12%) was to be followed in most of the DDIs.
CONCLUSION
This study assists in understanding the factors associated with DDIs that can help in safe and effective use of drugs in the future.
目的
本研究旨在通过对一家印度南部教学医院住院患者的处方分析来评估药物-药物相互作用（DDI）。
方法
这是一项为期 6 个月的前瞻性观察性处方分析研究，从 2010 年 10 月至 2011 年 3 月进行。由病房主管医生选择疑似存在 DDI 的包含两种或更多种药物的处方。然后将处方中的药物输入药物相互作用检查器软件中。根据相互作用的机制、相互作用的严重程度、与开处的药物数量的关系以及疾病情况对 DDI 进行分类。
结果
共分析了 204 份处方，其中 186 份处方有 856 种 DDI。大多数 DDI 是药代动力学药物相互作用（42%），其次是未知机制（34%）和药效学机制（24%）。研究结果表明，心血管疾病与呼吸系统疾病的处方平均具有最多的药物相互作用。严重程度评估显示，大多数 DDI 为中度（70%），其次是轻度（28%）。研究结果表明，处方中药物数量的增加会导致 DDI 数量的增加。确定的干预措施表明，大多数 DDI 需要调整剂量（12%）。
结论
本研究有助于了解与 DDI 相关的因素，这有助于未来安全有效地使用药物。
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