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载有多西他赛的小型聚合物胶束可抑制临床相关的4T1小鼠乳腺癌模型中的远处转移。

Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model.

作者信息

Li Yunfei, Jin Mingji, Shao Shuai, Huang Wei, Yang Feifei, Chen Wei, Zhang Shenghua, Xia Guimin, Gao Zhonggao

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xiannongtan Street, Beijing 100050, PR China.

出版信息

BMC Cancer. 2014 May 10;14:329. doi: 10.1186/1471-2407-14-329.

DOI:10.1186/1471-2407-14-329
PMID:24885518
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4023534/
Abstract

BACKGROUND: The small size of ultra-small nanoparticles makes them suitable for lymphatic delivery, and many recent studies have examined their role in anti-metastasis therapy. However, the anti-metastatic efficacy of small-sized nanocarriers loaded with taxanes such as docetaxel has not yet been investigated in malignant breast cancer. METHODS: We encapsulated docetaxel using poly(D,L-lactide)1300-b-(polyethylene glycol-methoxy)2000 (mPEG2000-b-PDLLA1300) to construct polymeric micelles with a mean diameter of 16.76 nm (SPM). Patient-like 4T1/4T1luc breast cancer models in Balb/c mice, with resected and unresected primary tumors, were used to compare the therapeutic efficacies of SPM and free docetaxel (Duopafei) against breast cancer metastasis using bioluminescent imaging, lung nodule examination, and histological examination. RESULT: SPM showed similar efficacy to Duopafei in terms of growth suppression of primary tumors, but greater chemotherapeutic efficacy against breast cancer metastasis. In addition, lung tissue inflammation was decreased in the SPM-treated group, while many tumor cells and neutrophils were found in the Duopafei-treated group. CONCLUSION: Small-sized mPEG2000-b-PDLLA1300 micelles could provide an enhanced method of docetaxel delivery in breast cancer metastasis, and may represent a valid chemotherapeutic strategy in breast cancer patients with resected primary tumors.

摘要

背景：超小纳米颗粒体积小，适合淋巴输送，近期许多研究探讨了它们在抗转移治疗中的作用。然而，载有紫杉烷（如多西他赛）的小尺寸纳米载体在恶性乳腺癌中的抗转移疗效尚未得到研究。 方法：我们使用聚（D，L-丙交酯）1300-b-（聚乙二醇甲氧基）2000（mPEG2000-b-PDLLA1300）包裹多西他赛，构建平均直径为16.76 nm的聚合物胶束（SPM）。在Balb/c小鼠中建立类似患者的4T1/4T1luc乳腺癌模型，包括切除和未切除原发性肿瘤的模型，通过生物发光成像、肺结节检查和组织学检查，比较SPM和游离多西他赛（多帕菲）对乳腺癌转移的治疗效果。 结果：在原发性肿瘤生长抑制方面，SPM显示出与多帕菲相似的疗效，但对乳腺癌转移具有更高的化疗疗效。此外，SPM治疗组的肺组织炎症减轻，而多帕菲治疗组发现许多肿瘤细胞和中性粒细胞。 结论：小尺寸的mPEG2000-b-PDLLA1300胶束可为乳腺癌转移提供一种增强的多西他赛递送方法，可能代表了对已切除原发性肿瘤的乳腺癌患者一种有效的化疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/01636280071c/1471-2407-14-329-12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/bd5abe4044b6/1471-2407-14-329-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/625b5aedda4a/1471-2407-14-329-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/8094f17efd29/1471-2407-14-329-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/39326061dd56/1471-2407-14-329-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/5a5496fc25a0/1471-2407-14-329-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/5c0622200efb/1471-2407-14-329-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/0aee580f0f29/1471-2407-14-329-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/14647102569a/1471-2407-14-329-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/7af64d5f6197/1471-2407-14-329-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/5d9ad8c12088/1471-2407-14-329-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/497719d3e0da/1471-2407-14-329-11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/01636280071c/1471-2407-14-329-12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/bd5abe4044b6/1471-2407-14-329-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/625b5aedda4a/1471-2407-14-329-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/8094f17efd29/1471-2407-14-329-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/39326061dd56/1471-2407-14-329-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/5a5496fc25a0/1471-2407-14-329-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/5c0622200efb/1471-2407-14-329-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/0aee580f0f29/1471-2407-14-329-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/14647102569a/1471-2407-14-329-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/7af64d5f6197/1471-2407-14-329-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/5d9ad8c12088/1471-2407-14-329-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/497719d3e0da/1471-2407-14-329-11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d984/4023534/01636280071c/1471-2407-14-329-12.jpg

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[4]
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[5]
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[6]
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[7]
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[10]
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本文引用的文献

[1]
Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors.

J Control Release. 2013-7-14

[2]
Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden.

Surgery. 2013-3-13

[3]
Imaging metastasis using an integrin-targeting chain-shaped nanoparticle.

ACS Nano. 2012-9-24

[4]
Strategies for the discovery and development of therapies for metastatic breast cancer.

Nat Rev Drug Discov. 2012-6-1

[5]
Stability influences the biodistribution, toxicity, and anti-tumor activity of doxorubicin encapsulated in PEG-PE micelles in mice.

Pharm Res. 2012-3-17

[6]
Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis.

J Control Release. 2012-2-3

[7]
Treating metastatic cancer with nanotechnology.

Nat Rev Cancer. 2011-12-23

[8]
Improving intraperitoneal chemotherapeutic effect and preventing postsurgical adhesions simultaneously with biodegradable micelles.

Nanomedicine. 2011-11-15

[9]
Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles.

Biomaterials. 2011-5-4

[10]
Synergy of nab-paclitaxel and bevacizumab in eradicating large orthotopic breast tumors and preexisting metastases.

Neoplasia. 2011-4

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