David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Nat Rev Cancer. 2011 Dec 23;12(1):39-50. doi: 10.1038/nrc3180.
Metastasis accounts for the vast majority of cancer deaths. The unique challenges for treating metastases include their small size, high multiplicity and dispersion to diverse organ environments. Nanoparticles have many potential benefits for diagnosing and treating metastatic cancer, including the ability to transport complex molecular cargoes to the major sites of metastasis, such as the lungs, liver and lymph nodes, as well as targeting to specific cell populations within these organs. This Review highlights the research, opportunities and challenges for integrating engineering sciences with cancer biology and medicine to develop nanotechnology-based tools for treating metastatic disease.
转移是癌症死亡的主要原因。治疗转移的独特挑战包括其体积小、多发性和分散到不同的器官环境。纳米颗粒在诊断和治疗转移性癌症方面具有许多潜在的优势，包括将复杂的分子货物运输到主要的转移部位（如肺、肝和淋巴结）的能力，以及针对这些器官内特定细胞群体的靶向能力。这篇综述强调了将工程科学与癌症生物学和医学相结合，开发基于纳米技术的治疗转移性疾病的工具的研究、机遇和挑战。
