Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Rehabilitation Medicine, Sahlgrenska Academy, University of Gothenburg, Per Dubbsgatan 14, 413 45 Göteborg, Sweden.
J Neuroeng Rehabil. 2014 May 9;11:83. doi: 10.1186/1743-0003-11-83.
A frequently used clinical test to assess mobility after stroke is the Timed Up & Go. Knowledge regarding whether or not the Timed Up & Go is able to detect change over time in patients with stroke, whether improvements in mobility exist after the first three months and whether or not longitudinal change in mobility after stroke depend on the patients' age, is limited or unclear. The objectives were to investigate the distribution-based responsiveness of the Timed Up & Go (TUG) during the first three months after a first event of stroke, to measure the longitudinal change in TUG time during the first year after stroke and to establish whether recovery in TUG time differs between different age groups.
Ninety-one patients with first-ever stroke were assessed using the Timed Up & Go at the 1st week and at 3, 6 and 12 months after stroke. The non-parametric sign-test, the parametric t-test and a mixed model approach to linear regression for repeated measurements (Proc mixed) were used for the statistical analyses.
The median TUG time was reduced from 17 to 12 seconds (p < 0.001) between the 1st week and 3 months. No further improvement was seen between 3 and 12 months after stroke. In a mixed model approach to linear regression, there was a significant age difference. Patients at age 80 and above tended to deteriorate in terms of TUG time between 3 and 12 months after stroke, while patients < 80 years did not (p = 0.011 for the interaction between age group and time).
The Timed Up & Go demonstrates ability to detect change in mobility over time in patients with stroke. A significant improvement in TUG time from the 1st week to 3 months after stroke was found, as expected, but thereafter no statistically significant change was detected. After 3 months, patients ≥80 years tended to deteriorate in terms of TUG time, while the younger patients did not.
评估中风后活动能力的常用临床测试是计时起立行走测试（Timed Up & Go）。目前，人们对以下问题的认识有限或并不明确，即计时起立行走测试是否能够检测到中风患者随时间推移的变化，在中风后前三个月是否存在活动能力的改善，以及中风后活动能力的纵向变化是否取决于患者的年龄。本研究旨在调查首次中风后前三个月计时起立行走测试的基于分布的反应性，测量中风后第一年计时起立行走测试时间的纵向变化，并确定计时起立行走测试时间的恢复是否因年龄组不同而有所差异。
91 例首发中风患者在中风后第 1 周和第 3、6 和 12 个月接受计时起立行走测试。采用非参数符号检验、参数 t 检验和重复测量线性回归的混合模型方法（Proc mixed）进行统计分析。
计时起立行走测试时间中位数从第 1 周的 17 秒降低到第 3 个月的 12 秒（p<0.001）。中风后 3 个月至 12 个月之间没有进一步的改善。在线性回归的混合模型方法中，年龄存在显著差异。80 岁及以上的患者在中风后 3 至 12 个月之间，计时起立行走测试时间趋于恶化，而年龄<80 岁的患者则没有（年龄组和时间之间的交互作用 p=0.011）。
计时起立行走测试能够检测中风患者随时间推移的活动能力变化。从第 1 周到中风后 3 个月，计时起立行走测试时间显著改善，这是预期的结果，但此后未检测到统计学上的显著变化。3 个月后，80 岁及以上的患者在计时起立行走测试时间方面趋于恶化，而年轻患者则没有。
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