Barry Emma, Galvin Rose, Keogh Claire, Horgan Frances, Fahey Tom
HRB Centre for Primary Care research, Department of General Practice, Royal College of Surgeons in Ireland, 123 St, Stephens Green, Dublin 2, Republic of Ireland.
BMC Geriatr. 2014 Feb 1;14:14. doi: 10.1186/1471-2318-14-14.
The Timed Up and Go test (TUG) is a commonly used screening tool to assist clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-analysis is to determine the overall predictive value of the TUG in community-dwelling older adults.
A literature search was performed to identify all studies that validated the TUG test. The methodological quality of the selected studies was assessed using the QUADAS-2 tool, a validated tool for the quality assessment of diagnostic accuracy studies. A TUG score of ≥13.5 seconds was used to identify individuals at higher risk of falling. All included studies were combined using a bivariate random effects model to generate pooled estimates of sensitivity and specificity at ≥13.5 seconds. Heterogeneity was assessed using the variance of logit transformed sensitivity and specificity.
Twenty-five studies were included in the systematic review and 10 studies were included in meta-analysis. The TUG test was found to be more useful at ruling in rather than ruling out falls in individuals classified as high risk (>13.5 sec), with a higher pooled specificity (0.74, 95% CI 0.52-0.88) than sensitivity (0.31, 95% CI 0.13-0.57). Logistic regression analysis indicated that the TUG score is not a significant predictor of falls (OR = 1.01, 95% CI 1.00-1.02, p = 0.05).
The Timed Up and Go test has limited ability to predict falls in community dwelling elderly and should not be used in isolation to identify individuals at high risk of falls in this setting.
定时起立行走测试(TUG)是一种常用的筛查工具,可帮助临床医生识别有跌倒风险的患者。本系统评价和荟萃分析的目的是确定TUG在社区居住的老年人中的总体预测价值。
进行文献检索以识别所有验证TUG测试的研究。使用QUADAS-2工具评估所选研究的方法学质量,QUADAS-2是一种用于诊断准确性研究质量评估的经过验证的工具。TUG评分≥13.5秒用于识别跌倒风险较高的个体。所有纳入的研究使用双变量随机效应模型进行合并,以生成≥13.5秒时敏感性和特异性的合并估计值。使用对数转换敏感性和特异性的方差评估异质性。
系统评价纳入25项研究,荟萃分析纳入10项研究。发现TUG测试在判定高危(>13.5秒)个体跌倒方面比排除跌倒更有用,合并特异性(0.74,95%CI 0.52-0.88)高于敏感性(0.31,95%CI 0.13-0.57)。逻辑回归分析表明,TUG评分不是跌倒的显著预测因素(OR = 1.01,95%CI 1.00-1.02,p = 0.05)。
定时起立行走测试预测社区居住老年人跌倒的能力有限,不应单独用于识别该环境中跌倒风险高的个体。