McMahon Daria M, Vdovenko Vitaliy Y, Karmaus Wilfried, Kondrashova Valentina, Svendsen Erik, Litvinetz Oksana M, Stepanova Yevgenia I
Division of Epidemiology, Biostatistics, and Environmental Health Science, School of Public Health University of Memphis, 301 Robison Hall, Memphis 38152 TN, USA.
Environ Health. 2014 May 10;13(1):36. doi: 10.1186/1476-069X-13-36.
After the Chernobyl nuclear incident in 1986, children in the Narodichesky region, located 80 km west of the Chernobyl Power Plant, were exposed to 137Cesium (137Cs). Little is known about the effects of chronic low-level radiation on humoral immune responses in children residing in contaminated areas.
In four different approaches we investigated the effect of residential 137Cs exposure on immunoglobulins A, G, M, and specific immunoglobulin E in children. In a dynamic cohort (1993-1998) we included 617 children providing 2,407 repeated measurements; 421 and 523 children in two cross-sectional samples (1997-1998 and 2008-2010, respectively); and 25 participants in a small longitudinal cohort (1997-2010). All medical exams, blood collections, and analyses were conducted by the same team. We used mixed linear models to analyze repeated measurements in cohorts and general linear regression models for cross-sectional studies.
Residential soil contamination in 2008 was highly correlated with the individual body burden of 137Cs. Serum IgG and IgM concentrations increased between 1993 and 1998. Children with higher 137Cs soil exposure had lower serum IgG levels, which, however, increased in the small cohort assessed between 1997 and 2010. Children within the fourth quintile of 137Cs soil exposure (266-310 kBq/m2) had higher IgM serum concentrations between 1993 and 1998 but these declined between 1997 and 2010. IgA remained stable with median 137Cs exposures related to higher IgA levels, which was corroborated in the cross-sectional study of 2008-2010. Specific IgE against indoor allergens was detected less often in children with higher 137Cs exposure.
Our findings show radiation-related alterations of immunoglobulins which by themselves do not constitute adverse health effects. Further investigations are necessary to understand how these changes affect health status.
1986年切尔诺贝利核事故后，位于切尔诺贝利核电站以西80公里的纳罗迪切斯基地区的儿童受到了137铯（137Cs）的辐射。关于长期低剂量辐射对居住在污染地区儿童体液免疫反应的影响，人们了解甚少。
我们采用四种不同方法，研究了居住环境中137Cs暴露对儿童免疫球蛋白A、G、M和特异性免疫球蛋白E的影响。在一个动态队列（1993 - 1998年）中，我们纳入了617名儿童，进行了2407次重复测量；在两个横断面样本（分别为1997 - 1998年和2008 - 2010年）中，分别有421名和523名儿童；在一个小型纵向队列（1997 - 2010年）中有25名参与者。所有医学检查、血液采集和分析均由同一团队进行。我们使用混合线性模型分析队列中的重复测量数据，并使用一般线性回归模型进行横断面研究。
2008年居住土壤污染与个体137Cs体内负荷高度相关。1993年至1998年期间，血清IgG和IgM浓度升高。137Cs土壤暴露量较高的儿童血清IgG水平较低，但在1997年至2010年评估的小型队列中有所升高。137Cs土壤暴露处于第四五分位数（266 - 310 kBq/m²）的儿童在1993年至1998年期间血清IgM浓度较高，但在1997年至2010年期间有所下降。IgA保持稳定，137Cs暴露中位数与较高的IgA水平相关，这在2008 - 2010年的横断面研究中得到了证实。137Cs暴露量较高的儿童中，针对室内过敏原的特异性IgE检测频率较低。
我们的研究结果显示了与辐射相关的免疫球蛋白变化，这些变化本身并不构成不良健康影响。需要进一步调查以了解这些变化如何影响健康状况。
Zotero 插件
