Irkeç C, Ercan S, Irkeç M
Gazi Universitesi, Tip Fakültesi, Nöroloji Anabilim Dali.
Mikrobiyol Bul. 1989 Oct;23(4):342-7.
Assessment of Leukotriene C4 (LTC4) activity in the serum and cerebrospinal fluid (CSF) specimens of patients with multiple sclerosis (MS), Parkinson's disease, amyotrophic lateral sclerosis (ALS), Myasthenia gravis (MG), Behçet's disease and neuro-Behçet, as well as in normal controls were carried out in order to determine its role in the pathogenesis of neurologic disorders. LTC4 levels were found to be elevated in MS and Behçet patient in comparison with controls. Augmentation of LTC4 levels underlines the fact that leukotrienes may be held responsible the pathogenesis of these disorders.
为了确定白三烯C4（LTC4）在神经系统疾病发病机制中的作用，对多发性硬化症（MS）、帕金森病、肌萎缩侧索硬化症（ALS）、重症肌无力（MG）、白塞病和神经白塞病患者以及正常对照者的血清和脑脊液（CSF）标本中的LTC4活性进行了评估。发现与对照组相比，MS和白塞病患者的LTC4水平升高。LTC4水平的升高突出了白三烯可能是这些疾病发病机制原因的这一事实。
