Zhang Xin, Yang Yong, Wang Qi
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Urology, Peking University Cancer Hospital & Institute, Beijing 100020, China.
Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Email:
Chin Med J (Engl). 2014;127(11):2143-6.
Epidemiological studies have shown that lycopene has anti-prostate cancer effect. In vitro tests also confirmed that it can promote apoptosis of prostate cancer cells. We investigated the effect of whole-tomato supplement lycopene on the prostate-specific antigen velocity in selected prostate cancer patients.
Twenty selected prostate cancer patients were given whole-tomato supplement lycopene 10 mg per day for about 6 months. Blood samples of patients were collected weekly to measure serum prostate-specific antigen (PSA) values. PSA velocity slope, which reflects the change of PSA, and the degree of change were also calculated. By comparing the values of average PSA velocity slope (rise or fall of PSA) before and after the administration of lycopene, the effect of lycopene can be evaluated. Blood chemistry analysis was regular followed as safety control.
Three patients in the research group withdrew within 3 weeks because of inability to conform. The rest 17 patients continued for an average period of 6 months. Two patients withdrew because of cancer progression (PSA rise) who later received active treatment. The average fall in PSA was equivalent to 2.56% over (i.e. an average slope/d of -0.000 28) the first 3 months. In the last 3 months, average fall in PSA was equivalent to 31.58% (i.e. an average slope/d of -0.003 51). The Wilcoxon rank-sum test showed a statistically significant decrease of PSA velocity slope overall (P = 0.000 9). Analysis of the PSA doubling time (pre- vs. post-treatment) showed a median increase over 3 months but this was not statistically significant (P = 0.21). No toxic side effect was observed during the whole process. The results indicate that the average PSA change is "decline" in patients, and the degree of the decline is accelerated.
Administration of lycopene was able to reduce PSA velocity in this study group.
流行病学研究表明，番茄红素具有抗前列腺癌作用。体外试验也证实其可促进前列腺癌细胞凋亡。我们研究了全番茄补充剂番茄红素对部分前列腺癌患者前列腺特异性抗原变化速度的影响。
选取20例前列腺癌患者，给予全番茄补充剂番茄红素，每日10毫克，持续约6个月。每周采集患者血样以测定血清前列腺特异性抗原（PSA）值。还计算了反映PSA变化的PSA速度斜率及其变化程度。通过比较服用番茄红素前后平均PSA速度斜率（PSA的上升或下降）的值，可评估番茄红素的效果。定期进行血液化学分析作为安全性对照。
研究组中有3例患者因无法依从在3周内退出。其余17例患者平均持续了6个月。2例患者因癌症进展（PSA升高）退出，随后接受了积极治疗。在最初3个月中，PSA平均下降相当于2.56%（即平均斜率/天为-0.00028）。在最后3个月中，PSA平均下降相当于31.58%（即平均斜率/天为-0.00351）。Wilcoxon秩和检验显示，总体上PSA速度斜率有统计学意义的下降（P = 0.0009）。PSA倍增时间（治疗前与治疗后）分析显示，3个月内中位数有所增加，但无统计学意义（P = 0.21）。整个过程中未观察到毒副作用。结果表明，患者的PSA平均变化呈“下降”趋势，且下降程度加快。
在本研究组中，服用番茄红素能够降低PSA速度。
