DNA 降解及其缺陷。
DNA degradation and its defects.
机构信息
Department of Medical Chemistry, Kyoto University Graduate School of Medicine, Yoshida-Konoe, Kyoto 606-8501, Japan.
Department of Medical Chemistry, Kyoto University Graduate School of Medicine, Yoshida-Konoe, Kyoto 606-8501, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Yoshida-Konoe, Kyoto 606-8501, Japan.
出版信息
Cold Spring Harb Perspect Biol. 2014 Jun 2;6(6):a016394. doi: 10.1101/cshperspect.a016394.
Abstract
DNA is one of the most essential molecules in organisms, containing all the information necessary for organisms to live. It replicates and provides a mechanism for heredity and evolution. Various events cause the degradation of DNA into nucleotides. DNA also has a darker side that has only recently been recognized; DNA that is not properly degraded causes various diseases. In this review, we discuss four deoxyribonucleases that function in the nucleus, cytosol, and lysosomes, and how undigested DNA causes such diseases as cancer, cataract, and autoinflammation. Studies on the biochemical and physiological functions of deoxyribonucleases should continue to increase our understanding of cellular functions and human diseases.
摘要
DNA 是生物体内最重要的分子之一，包含生物体生存所需的所有信息。它复制并提供遗传和进化的机制。各种事件导致 DNA 降解为核苷酸。DNA 还有一个最近才被认识到的阴暗面；未被正确降解的 DNA 会导致各种疾病。在这篇综述中，我们讨论了在核、细胞质和溶酶体中发挥作用的四种脱氧核糖核酸酶，以及未消化的 DNA 如何导致癌症、白内障和自身炎症等疾病。脱氧核糖核酸酶的生化和生理功能研究应继续增加我们对细胞功能和人类疾病的理解。
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