Song Wen-Jun, Wei Ji-Ping, Wang Su-Ying, Wang Huai-Song
Tianjin Key Laboratory of Food Biotechnology, Tianjin University of Commerce, Tianjin 300134, China.
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Anal Chim Acta. 2014 Jun 17;832:58-64. doi: 10.1016/j.aca.2014.04.063. Epub 2014 May 2.
Novel hydrophilic microparticles containing β-cyclodextrin (β-CD) were prepared via one-pot synthesis using reversible addition-fragmentation chain-transfer (RAFT) precipitation polymerization, a "controlled/living" radical polymerization technique. The polymerization was initiated by hydrophilic macromolecular chain-transfer agent [poly(2-hydroxyethyl methacrylate), PHEMA]. The hydrophilic PHEMA on the surface of microparticles can well improve their surface hydrophilicity and lead to their biological compatibility. As chiral restricted access material (RAM), the hydrophilic microparticles can be used for determination of enantiomers in biological samples with direct injection via HPLC analysis.
