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与美国透析机构中低肾移植率相关的透析机构和网络因素。

Dialysis facility and network factors associated with low kidney transplantation rates among United States dialysis facilities.

机构信息

Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA; Department of Epidemiology, Rollins School of Public Health, Atlanta, GA.

出版信息

Am J Transplant. 2014 Jul;14(7):1562-72. doi: 10.1111/ajt.12749. Epub 2014 May 29.

Abstract

Variability in transplant rates between different dialysis units has been noted, yet little is known about facility-level factors associated with low standardized transplant ratios (STRs) across the United States End-stage Renal Disease (ESRD) Network regions. We analyzed Centers for Medicare & Medicaid Services Dialysis Facility Report data from 2007 to 2010 to examine facility-level factors associated with low STRs using multivariable mixed models. Among 4098 dialysis facilities treating 305 698 patients, there was wide variability in facility-level STRs across the 18 ESRD Networks. Four-year average STRs ranged from 0.69 (95% confidence interval [CI]: 0.64-0.73) in Network 6 (Southeastern Kidney Council) to 1.61 (95% CI: 1.47-1.76) in Network 1 (New England). Factors significantly associated with a lower STR (p < 0.0001) included for-profit status, facilities with higher percentage black patients, patients with no health insurance and patients with diabetes. A greater number of facility staff, more transplant centers per 10 000 ESRD patients and a higher percentage of patients who were employed or utilized peritoneal dialysis were associated with higher STRs. The lowest performing dialysis facilities were in the Southeastern United States. Understanding the modifiable facility-level factors associated with low transplant rates may inform interventions to improve access to transplantation.

摘要

不同透析单位之间的移植率存在差异,但对于美国终末期肾病(ESRD)网络区域内与低标准化移植率(STR)相关的设施水平因素知之甚少。我们分析了 2007 年至 2010 年医疗保险和医疗补助服务中心透析设施报告数据,使用多变量混合模型检查与低 STR 相关的设施水平因素。在治疗 305698 名患者的 4098 家透析设施中,18 个 ESRD 网络之间的设施水平 STR 差异很大。四年平均 STR 范围从第 6 网络(东南肾脏委员会)的 0.69(95%置信区间[CI]:0.64-0.73)到第 1 网络(新英格兰)的 1.61(95%CI:1.47-1.76)。与 STR 较低显著相关的因素(p < 0.0001)包括营利性地位、黑种人患者比例较高的设施、无医疗保险的患者和患有糖尿病的患者。设施员工人数较多、每 10000 名 ESRD 患者的移植中心数量较多以及更多的患者就业或使用腹膜透析与较高的 STR 相关。表现最差的透析设施位于美国东南部。了解与低移植率相关的可修改设施水平因素可能有助于为改善移植机会提供信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b42/4180229/4732c0382aff/nihms627870f1.jpg

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