Psychiatric Unit and Department of Palliative Care, Tata Memorial Hospital, Dr. E Borges Road, Parel, Mumbai, Maharashtra, India.
Department of Medical Oncology, Tata Memorial Hospital, Dr. E Borges Road, Parel, Mumbai, Maharashtra, India.
Indian J Psychiatry. 2014 Apr;56(2):191-3. doi: 10.4103/0019-5545.130507.
The judiciousness of the use of clozapine in patients with schizophrenia in clinical practice is brought to an even sharper focus when it has to be used in combination with other agents that cause myelosuppression, for example, chemotherapy and radiation treatment. There are a few references till date illustrating the combination of clozapine and chemotherapy and/or radiation therapy. To the best of our knowledge, such a case has not been reported from India. We report the case of a 39-year-old gentleman with a diagnosis of schizophrenia, remaining psychiatrically stable on clozapine, who underwent combination treatment of chemotherapy and radiotherapy for the treatment of cancer of the tongue in a tertiary care oncology centre in India.
在临床实践中，氯氮平在精神分裂症患者中的使用是否合理，当它必须与其他引起骨髓抑制的药物联合使用时，就会更加凸显出来，例如化疗和放射治疗。目前有一些参考文献说明了氯氮平和化疗和/或放射治疗的联合使用。据我们所知，这种情况在印度尚未有报道。我们报告了一例 39 岁男性患者，诊断为精神分裂症，服用氯氮平后精神状态稳定，在印度一家三级肿瘤中心接受化疗和放疗联合治疗舌癌。
