Pakhre Ashish, Krishnan Aarya, Pattanayak Raman Deep, Khandelwal Sudhir K
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
Indian J Psychiatry. 2016 Oct-Dec;58(4):462-466. doi: 10.4103/0019-5545.196711.
Regular monitoring of blood counts ensures the safety of clozapine use; however, certain clinical situations may pose a dilemma for management such as use of clozapine in the presence of myelosuppressive chemotherapy. Further, there is very limited literature to guide such decisions. We report a case of a clozapine-stabilized, treatment-resistant bipolar disorder patient with ovarian carcinoma requiring chemotherapy. The clinical challenges are discussed in light of a brief review of the available reports.
定期监测血细胞计数可确保氯氮平使用的安全性；然而，某些临床情况可能给管理带来两难局面，例如在存在骨髓抑制性化疗的情况下使用氯氮平。此外，指导此类决策的文献非常有限。我们报告一例患有卵巢癌且需要化疗的、使用氯氮平病情稳定的难治性双相情感障碍患者。结合对现有报告的简要回顾，对临床挑战进行了讨论。
