Adult Neurodevelopmental Services, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, 1001 Queen Street West, Unit 4, Toronto, ON, M6J 1H4, Canada.
Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Canada.
J Autism Dev Disord. 2018 Oct;48(10):3637-3640. doi: 10.1007/s10803-018-3589-7.
There is paucity of empirical data regarding the use of either clozapine or electroconvulsive therapy (ECT) in the acute phase and maintenance treatment of schizophrenia in adults with intellectual disability. Herein we report the successful acute and long-term remission of psychotic symptoms and catatonia with the combination of clozapine and ECT in a 26-year-old female with moderate ID and treatment-resistant schizophrenia. To our knowledge, this is the first case example of the successful use of the combination of bilateral, standard-pulse ECT and clozapine in both acute and long-term treatment of treatment-resistant schizophrenia and catatonia in an adult with ID. Our report adds further support to the emerging evidence regarding the efficacy and safety of this combination in treatment-resistant schizophrenia.
关于在智力障碍成年人精神分裂症的急性期和维持治疗中使用氯氮平或电抽搐治疗（ECT），经验数据很少。在此，我们报告了一例 26 岁中度智力障碍、治疗抵抗性精神分裂症患者，氯氮平和 ECT 联合使用成功缓解精神病症状和紧张症。据我们所知，这是首例双侧标准脉冲 ECT 和氯氮平联合用于治疗智力障碍成人治疗抵抗性精神分裂症和紧张症的急性和长期治疗的成功案例。我们的报告为氯氮平联合 ECT 治疗治疗抵抗性精神分裂症的疗效和安全性提供了更多支持。
