Shaikh Sidra Mumtaz, Faisal Sobia, Khyani Iqbal A M, Sikandar Bushra
Dow University of Health Sciences, Former House Officers, Civil Hospital Karachi, Pakistan.
Department of ENT, Head and Neck Surgery, Dow University of Health Sciences, Karachi, Pakistan.
World J Oncol. 2016 Aug;7(4):85-90. doi: 10.14740/wjon978w. Epub 2016 Sep 3.
Rhabdomyosarcoma (RMS) is a soft tissue neoplasm of mesenchymal origin. It is a commonly encountered malignant tumor amongst pediatric patients, yet relatively rare in adults. It usually involves the head and neck region, genitourinary organs and retroperitoneal structures. In adults, the most commonly affected area is the head and neck region. We present here a case of a 30-year-old male patient with a primary squamous cell carcinoma of the tongue (T1, N0, M1), successfully cured with surgery and chemoradiotherapy and later on development of metachronous ipsilateral lesion on the left lower alveolus. Biopsy was consistent with spindle cell RMS. Immunohistochemistry demonstrated positivity for desmin, vimentin and myogenin, thus confirming the mesenchymal origin. With the best of our literature search, this is an exceptional case presenting two malignant lesions with diverse genetic origins, diagnosed at stage 1 and giving a favorable outcome.
横纹肌肉瘤（RMS）是一种间叶组织起源的软组织肿瘤。它是儿科患者中常见的恶性肿瘤，但在成人中相对罕见。它通常累及头颈部区域、泌尿生殖器官和腹膜后结构。在成人中，最常受累的部位是头颈部区域。我们在此报告一例30岁男性患者，患有原发性舌鳞状细胞癌（T1，N0，M1），经手术及放化疗成功治愈，随后左下颌牙槽出现异时性同侧病变。活检结果与梭形细胞RMS一致。免疫组化显示结蛋白、波形蛋白和肌细胞生成素呈阳性，从而证实了间叶组织起源。据我们所能进行的文献检索，这是一例特殊病例，呈现出两个具有不同遗传起源的恶性病变，诊断为1期且预后良好。
