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成人幕下髓母细胞瘤酷似脑膜瘤:一例报告及系统综述

Adult tentorial medulloblastoma mimicking meningioma: A case report and systematic review.

作者信息

Eid Sadeen Sameer, Ali Arshad, Shah Noman, Alawadat Amal I, AbuHejleh Muna, Al-Bozom Issam, Al-Sulaiti Ghanem

机构信息

Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Department of Neurosurgery, Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.

出版信息

Surg Neurol Int. 2025 Apr 18;16:143. doi: 10.25259/SNI_10_2025. eCollection 2025.

Abstract

BACKGROUND

Tentorial medulloblastomas in adults are exceedingly rare and may clinically and radiologically mimic meningiomas. This case report, with a systematic review, aims to outline the clinical, radiological, pathological, and management strategies for adult tentorial medulloblastoma.

CASE DESCRIPTION

A 37-year-old male patient presented with headaches, vertigo, and vomiting. Imaging investigations revealed a tentorial extra-axial mass, initially considered a meningioma. The patient subsequently underwent surgical resection followed by chemoradiation. Histopathological examination ultimately identified the mass as an eccentrically located adult medulloblastoma. We conducted a systematic review of the literature, analyzing four studies that reported similar cases. This analysis included clinical and demographic information, diagnosis through imaging and histopathology, treatment methods, and outcomes for seven cases, including our own.

CONCLUSION

Adult tentorial medulloblastomas are extremely rare tumors that may mimic meningiomas, posing significant clinical challenges. Accurate diagnosis necessitates advanced imaging techniques and histopathological confirmation. The primary treatment strategy involves maximal surgical resection, supplemented by chemoradiotherapy.

摘要

背景

成人小脑幕髓母细胞瘤极为罕见,在临床和影像学上可能类似脑膜瘤。本病例报告并进行系统综述,旨在概述成人小脑幕髓母细胞瘤的临床、影像学、病理学及治疗策略。

病例描述

一名37岁男性患者出现头痛、眩晕和呕吐症状。影像学检查发现小脑幕区轴外肿块,最初考虑为脑膜瘤。该患者随后接受了手术切除,之后进行了放化疗。组织病理学检查最终确定该肿块为偏心性成人髓母细胞瘤。我们对文献进行了系统综述,分析了四项报告类似病例的研究。该分析包括临床和人口统计学信息、通过影像学和组织病理学进行的诊断、治疗方法以及包括我们自己的病例在内的七例患者的治疗结果。

结论

成人小脑幕髓母细胞瘤是极为罕见的肿瘤,可能类似脑膜瘤,带来重大临床挑战。准确诊断需要先进的影像学技术和组织病理学确认。主要治疗策略包括最大限度的手术切除,并辅以放化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957d/12065501/fed4b63218f8/SNI-16-143-g001.jpg

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