Department of Internal Medicine, Medical University of Silesia in Katowice, Bytom 41-902, Poland.
Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan 60-806, Poland.
Exp Biol Med (Maywood). 2020 Aug;245(14):1260-1267. doi: 10.1177/1535370220929621. Epub 2020 May 29.
Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor.
胰岛素抵抗与导致心血管疾病的氧化应激有关。然而，针对是否存在胰岛素抵抗的老年个体的研究很少。我们证明，抗氧化防御系统本身并不能消除患动脉粥样硬化高风险的老年个体的胰岛素作用，而氧化应激-抗氧化标志物（硫代巴比妥酸反应物质（TBARS）、Cu，Zn-超氧化物歧化酶（SOD-1）和总抗氧化状态（TAS））可能更有效，或许能产生更好的临床效果。事实上，只有在胰岛素抵抗的老年个体中才会看到氧化应激的降低和抗氧化防御之间的强烈相互作用。在我们看来，这对于临床医生来说是有价值的信息，因为胰岛素抵抗被认为是一个强烈的心血管风险因素。
